Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

P53 is known as the most critical tumor suppressor and is often referred to as the guardian of
our genome. More than 40 years after its discovery, we are still struggling to understand all …

Perfectly orchestrated periodic gene expression during cell cycle progression is essential for
maintaining genome integrity and ensuring that cell proliferation can be stopped by …

Deciphering the mechanisms that control the pluripotent ground state is key for
understanding embryonic development. Nonetheless, the epigenetic regulation of ground …

The DREAM complex orchestrates cell quiescence and the cell cycle. However, how the
DREAM complex is deregulated in cancer remains elusive. Here, we report that PAF …

The DREAM complex represses cell cycle genes during quiescence through scaffolding
MuvB proteins with E2F4/5 and the Rb tumor suppressor paralog p107 or p130. Upon cell …

Emerging evidence points to aberrant regulation of translation as a driver of cell
transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA …

YAP and TAZ, downstream effectors of the Hippo pathway, are important regulators of
proliferation. Here, we show that the ability of YAP to activate mitotic gene expression is …