New frontiers in selective human MAO-B inhibitors: miniperspective
S Carradori, R Silvestri - Journal of medicinal chemistry, 2015 - ACS Publications
Accumulating evidence shows a relationship between the human MAO-B (hMAO-B) enzyme
and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline …
and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline …
Inhibitor design for monoamine oxidases
R R. Ramsay - Current pharmaceutical design, 2013 - benthamdirect.com
Flavin-containing monoamine oxidases (MAO A and MAO B) located on the outer
membrane of mitochondria oxidise amines and generate hydrogen peroxide. Inhibitors …
membrane of mitochondria oxidise amines and generate hydrogen peroxide. Inhibitors …
New pyrazoline bearing 4 (3H)-quinazolinone inhibitors of monoamine oxidase: Synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B …
N Gökhan-Kelekçi, S Koyunoğlu, S Yabanoğlu… - Bioorganic & medicinal …, 2009 - Elsevier
A new series of pyrazoline derivatives were prepared starting from a quinazolinone ring and
evaluated for antidepressant, anxiogenic and MAO-A and-B inhibitory activities by in vivo …
evaluated for antidepressant, anxiogenic and MAO-A and-B inhibitory activities by in vivo …
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo [d] imidazol-2-yl)
benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized …
benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized …
Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
Alzheimer's disease (AD) is a neurological, progressive illness that typically affects the
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b
TG Marshall, RE Lee, FE Marshall - Theoretical Biology and Medical …, 2006 - Springer
Background There have been indications that common Angiotensin Receptor Blockers
(ARBs) may be exerting anti-inflammatory actions by directly modulating the immune …
(ARBs) may be exerting anti-inflammatory actions by directly modulating the immune …
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as
monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to …
monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to …
Monoamine oxidase inhibitors: ten years of docking studies
The number of papers dealing with the structure-based drug design is continuously growing,
which demonstrates the importance of such tools in medicinal chemistry. In the current …
which demonstrates the importance of such tools in medicinal chemistry. In the current …
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors
In the recent works, it was shown that numerous thiazolylhydrazine derivatives display h
MAO inhibitory activity in the range of micromolar concentration. Hence, in the present study …
MAO inhibitory activity in the range of micromolar concentration. Hence, in the present study …
Computational insight into the mechanism of the irreversible inhibition of monoamine oxidase enzymes by the antiparkinsonian propargylamine inhibitors rasagiline …
T Tandarić, R Vianello - ACS Chemical Neuroscience, 2019 - ACS Publications
Monoamine oxidases (MAOs) are flavin adenine dinucleotide containing flavoenzymes that
catalyze the degradation of a range of brain neurotransmitters, whose imbalance is …
catalyze the degradation of a range of brain neurotransmitters, whose imbalance is …