This review paper provides an overview of the literature for topology optimisation of fluid-
based problems, starting with the seminal works on the subject and ending with a snapshot …

The design of periodic microstructural composite materials to achieve specific properties has
been a major area of interest in material research. Tailoring different physical properties by …

Scaffold permeability is a key parameter combining geometrical features such as pore
shape, size and interconnectivity, porosity and specific surface area. It can influence the …

Revision surgeries of total hip arthroplasty are often caused by a deficient structural
compatibility of the implant. Two main culprits, among others, are bone-implant interface …

Substantial tissue loss, such as in large bone defects, represents a clinical challenge for
which regenerative therapies and tissue engineering strategies aim at offering treatment …

In bone tissue engineering, the scaffold has not only to allow the diffusion of cells, nutrients
and oxygen but also provide adequate mechanical support. One way to ensure the scaffold …

The primary thrust of tissue engineering is the clinical translation of scaffolds and/or
biologics to reconstruct tissue defects. Despite this thrust, clinical translation of tissue …

In the development of artificial cancellous bones, two major factors need to be considered:
the integrity of the overall structure and its permeability. Whilst there have been many …

Bone scaffolds for tissue regeneration require an optimal trade-off between biological and
mechanical criteria. Optimal designs may be obtained using topology optimization …

Structural optimization is one of the most intensively investigated research areas in
engineering. Recently, topology optimization has become the most popular engineering …