Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …

Influenza virus affects the respiratory tract by direct viral infection or by damage from the
immune system response. In humans, the respiratory epithelium is the only site where the …

Objectives Patients with acute respiratory distress syndrome (ARDS) due to viral infection
are at risk for secondary complications like invasive aspergillosis. Our study evaluates …

We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and
influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited …

COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response
variation to disease severity and outcome over time, we longitudinally assessed circulating …

Glucocorticoids (GCs) are small lipid hormones produced by the adrenals that maintain
organismal homeostasis. Circadian and stress-induced changes in systemic GC levels …

Pulmonary diseases of viral origin are often followed by the manifestation of secondary
infections, leading to further clinical complications and negative disease outcomes. Thus …

The immune system probably evolved to limit the negative effects exerted by pathogens on
host homeostasis. This defence strategy relies on the concerted action of innate and …

Type I interferon (IFN) is a common therapy for autoimmune and inflammatory disorders, yet
the mechanisms of action are largely unknown. Here we showed that type I IFN inhibited …

Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …