Plasminogen and its active form, plasmin, have diverse functions related to the inflammatory
response in mammals. Due to these roles in inflammation, plasminogen has been …

Hemophilic arthropathy is a form of joint disease that develops secondary to joint bleeding
and presents with synovial hypertrophy, cartilage and bony destruction. The arthropathy can …

Our review is focused on the use of methotrexate in drug therapy of two autoimmune
diseases, psoriasis and rheumatoid arthritis (RA). The article describes the pathogenesis of …

Efficient migration of macrophages to sites of inflammation requires cell surface–bound
plasmin (ogen). Here, we investigated the mechanisms underlying the deficits of plasmin …

The musculoskeletal system is critical for movement and the protection of organs. In addition
to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated …

Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease characterized
in its early stages by synovial hyperplasia and inflammatory cell infiltration and later by …

Alzheimer's disease (AD) is a leading cause of age-related dementia worldwide. Despite
more than a century of intensive research, we are not anywhere near the discovery of a cure …

The musculoskeletal system plays vital roles in the body, facilitating movement, protecting
vital structures, and regulating hematopoiesis and mineral metabolism. Injuries to this …

Multiple sclerosis (MS) is a neuroinflammatory, demyelinating disease of the CNS.
Fibrinogen deposition at sites of blood–brain barrier breakdown is a prominent feature of …

Cartilage destruction is a key characteristic of arthritic disease, a process now widely
established to be mediated by metzincins such as MMPs. Despite showing promise in …