Neurodegenerative diseases: Regenerative mechanisms and novel therapeutic approaches
Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …
Protein aggregation: from background to inhibition strategies
The aggregation of specific proteins is hypothesized to cause several pathological
conditions, which are collectively known as amyloid disorders. The aggregation of peptides …
conditions, which are collectively known as amyloid disorders. The aggregation of peptides …
Vitamin k3 inhibits protein aggregation: implication in the treatment of amyloid diseases
Protein misfolding and aggregation have been associated with several human diseases
such as Alzheimer's, Parkinson's and familial amyloid polyneuropathy etc. In this study, anti …
such as Alzheimer's, Parkinson's and familial amyloid polyneuropathy etc. In this study, anti …
Protein misfolding and aggregation: Mechanism, factors and detection
Amyloidogenic diseases are characterised by the formation of amyloid aggregates inside or
outside the cell. Amyloid-associated human diseases include Alzheimer's disease …
outside the cell. Amyloid-associated human diseases include Alzheimer's disease …
Formation of rice protein fibrils is highly sensitive to the different types of metal ions: Aggregation behavior and possible mechanisms
Abstract The effects of Ca 2+, Cu 2+, and Fe 3+ on rice protein (RP) fibril formation were
investigated in this study. Low Ca 2+ concentration (≤ 150 mM) moderately unfolded the …
investigated in this study. Low Ca 2+ concentration (≤ 150 mM) moderately unfolded the …
Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity
P Alam, AZ Beg, MK Siddiqi, SK Chaturvedi… - Archives of biochemistry …, 2017 - Elsevier
Protein aggregation into oligomers and fibrils are associated with many human
pathophysiologies. Compounds that modulate protein aggregation and interact with …
pathophysiologies. Compounds that modulate protein aggregation and interact with …
Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
T Cao, W Zhang, Q Wang, C Wang, W Ma, C Zhang… - Cell, 2024 - cell.com
Taurine is used to bolster immunity, but its effects on antitumor immunity are unclear. Here,
we report that cancer-related taurine consumption causes T cell exhaustion and tumor …
we report that cancer-related taurine consumption causes T cell exhaustion and tumor …
Co-precipitation synthesis and characterization of Co doped SnO2 NPs, HSA interaction via various spectroscopic techniques and their antimicrobial and …
Sn 1-x Co x O 2 (x= 0.00, 0.01, 0.03, 0.05) nanoparticles (NPs) of average size∼ 30–40 nm
were synthesized by co-precipitation method. The interaction of Co doped SnO 2 NPs with …
were synthesized by co-precipitation method. The interaction of Co doped SnO 2 NPs with …
Vitamin B12 offers neuronal cell protection by inhibiting Aβ-42 amyloid fibrillation
Protein misfolding and aggregation has been implicated as the cause of more than 20
diseases in humans such as Alzheimer's and Parkinson's and systemic amyloidosis …
diseases in humans such as Alzheimer's and Parkinson's and systemic amyloidosis …
Mechanisms of amyloid proteins aggregation and their inhibition by antibodies, small molecule inhibitors, nano-particles and nano-bodies
Protein misfolding and aggregation can be induced by a wide variety of factors, such as
dominant disease-associated mutations, changes in the environmental conditions (pH …
dominant disease-associated mutations, changes in the environmental conditions (pH …