Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …

Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the
mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 …

Membrane dynamics are important to the integrity and function of mitochondria. Defective
mitochondrial fusion underlies the pathogenesis of multiple diseases. The ability to target …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

Membrane contact sites emerged in the last decade as key players in the integration,
regulation and transmission of many signals within cells, with critical impact in multiple …

Genetic mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD). Importantly, TDP-43 proteinopathy …

Abstract Charcot–Marie–Tooth disease (CMT) type 2A is a form of peripheral neuropathy,
due almost exclusively to dominant mutations in the nuclear gene encoding the …

Protein quality control ensures the degradation of damaged and misfolded proteins.
Derangement of proteostasis is a primary cause of aging and age‐associated diseases. The …