Persistent remodeling and neurodegeneration in late-stage retinal degeneration

RL Pfeiffer, RE Marc, BW Jones - Progress in retinal and eye research, 2020 - Elsevier
Retinal remodeling is a progressive series of negative plasticity revisions that arise from
retinal degeneration, and are seen in retinitis pigmentosa, age-related macular …

[HTML][HTML] Optogenetics for visual restoration: from proof of principle to translational challenges

M Lindner, MJ Gilhooley, S Hughes… - Progress in retinal and …, 2022 - Elsevier
Degenerative retinal disorders are a diverse family of diseases commonly leading to
irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent …

Photosensitivity of neurons enabled by cell-targeted gold nanoparticles

JL Carvalho-de-Souza, JS Treger, B Dang, SBH Kent… - Neuron, 2015 - cell.com
Unmodified neurons can be directly stimulated with light to produce action potentials, but
such techniques have lacked localization of the delivered light energy. Here we show that …

Photochemical restoration of visual responses in blind mice

A Polosukhina, J Litt, I Tochitsky, J Nemargut, Y Sychev… - Neuron, 2012 - cell.com
Retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are degenerative
blinding diseases caused by the death of rods and cones, leaving the remainder of the …

Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration

AC Weitz, D Nanduri, MR Behrend… - Science translational …, 2015 - science.org
Retinal prosthetic implants are the only approved treatment for retinitis pigmentosa, a
disease of the eye that causes blindness through gradual degeneration of photoreceptors …

Retinal ganglion cells survive and maintain normal dendritic morphology in a mouse model of inherited photoreceptor degeneration

F Mazzoni, E Novelli, E Strettoi - Journal of Neuroscience, 2008 - Soc Neuroscience
Retinitis pigmentosa (RP), a family of inherited disorders characterized by progressive
photoreceptor death, is a leading cause of blindness with no available cure. Despite the …

Cell replacement and visual restoration by retinal sheet transplants

MJ Seiler, RB Aramant - Progress in retinal and eye research, 2012 - Elsevier
Retinal diseases such as age-related macular degeneration (ARMD) and retinitis
pigmentosa (RP) affect millions of people. Replacing lost cells with new cells that connect …

Selective activation of neuronal targets with sinusoidal electric stimulation

DK Freeman, DK Eddington… - Journal of …, 2010 - journals.physiology.org
Electric stimulation of the CNS is being evaluated as a treatment modality for a variety of
neurological, psychiatric, and sensory disorders. Despite considerable success in some …

Electronic approaches to restoration of sight

GA Goetz, DV Palanker - Reports on Progress in Physics, 2016 - iopscience.iop.org
Retinal prostheses are a promising means for restoring sight to patients blinded by the
gradual atrophy of photoreceptors due to retinal degeneration. They are designed to …

Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa

J Pang, X Dai, SE Boye, I Barone, SL Boye, S Mao… - Molecular therapy, 2011 - cell.com
The retinal degeneration 10 (rd10) mouse is a well-characterized model of autosomal
recessive retinitis pigmentosa (RP), which carries a spontaneous mutation in the β subunit of …