[HTML][HTML] Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion
BS Song, JS Moon, J Tian, HY Lee… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Mitochondria are involved in cancer energy metabolism, although the
mechanisms underlying the involvement of mitoribosomal dysfunction in hepatocellular …
mechanisms underlying the involvement of mitoribosomal dysfunction in hepatocellular …
[HTML][HTML] miR-200c-3p, miR-222-5p, and miR-512-3p constitute a biomarker signature of sorafenib effectiveness in advanced hepatocellular carcinoma
P de la Cruz-Ojeda, T Schmid, L Boix, M Moreno… - Cells, 2022 - mdpi.com
Background: Sorafenib constitutes a suitable treatment alternative for patients with
advanced hepatocellular carcinoma (HCC) in whom atezolizumab+ bevacizumab therapy is …
advanced hepatocellular carcinoma (HCC) in whom atezolizumab+ bevacizumab therapy is …
[HTML][HTML] New insights into the role of mitochondrial metabolic dysregulation and immune infiltration in septic cardiomyopathy by integrated bioinformatics analysis and …
Background Septic cardiomyopathy (SCM), a common cardiovascular comorbidity of sepsis,
has emerged among the leading causes of death in patients with sepsis. SCM's …
has emerged among the leading causes of death in patients with sepsis. SCM's …
PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis
Q Sun, L Shi, S Li, J Li, R Zhang, X Huang… - Free Radical Biology …, 2023 - Elsevier
Cytochrome c oxidase, also known as complex IV, facilitates the transfer of electrons from
cytochrome c to molecular oxygen, resulting in the production of ATP. The assembly of …
cytochrome c to molecular oxygen, resulting in the production of ATP. The assembly of …
[HTML][HTML] N7-Methylguanosine genes related prognostic biomarker in hepatocellular carcinoma
P Regmi, ZQ He, T Lia, A Paudyal, FY Li - Frontiers in genetics, 2022 - frontiersin.org
Background: About 90% of liver cancer-related deaths are caused by hepatocellular
carcinoma (HCC). N7-methylguanosine (m7G) modification is associated with the biological …
carcinoma (HCC). N7-methylguanosine (m7G) modification is associated with the biological …
[HTML][HTML] MRPL12 acts as a novel prognostic biomarker involved in immune cell infiltration and tumor progression of lung adenocarcinoma
Y Hu, Y Liu, C Ma, K Ai - International Journal of Molecular Sciences, 2023 - mdpi.com
Mitochondrial ribosomal protein L7/L12 (MRPL12) is a member of the mitochondrial
ribosomal proteins (MRPs). However, the biological function of MRPL12 in lung …
ribosomal proteins (MRPs). However, the biological function of MRPL12 in lung …
Genomic and immune landscape in hepatocellular carcinoma: Implications for personalized therapeutics
J Zheng, J Chen, S Wang, D Yang… - Environmental …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a globally prevalent malignancy, marked by genetic
heterogeneity and intricate tumor microenvironment interactions. In this study, we undertook …
heterogeneity and intricate tumor microenvironment interactions. In this study, we undertook …
[HTML][HTML] MRPL21 promotes HCC proliferation through TP53 mutation-induced apoptotic resistance
T Ma, YB Huang, J Chen, L Zhang, YH Liu, CH Lu - Tissue and Cell, 2024 - Elsevier
Background and aims The specific mechanisms underlying the inhibition of hepatocellular
carcinoma (HCC) proliferation and metastasis by mitochondrial apoptosis are not yet fully …
carcinoma (HCC) proliferation and metastasis by mitochondrial apoptosis are not yet fully …
[HTML][HTML] Multi-omics analysis of MRPL-13 as a tumor-promoting marker from pan-cancer to lung adenocarcinoma
X Zhong, Z He, Y Fan, L Yin, Z Hong, Y Tong… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Background: As a member of the mitochondrial ribosomal protein family, mitochondrial
ribosomal protein L13 (MRPL13) is responsible for synthesizing mitochondrial proteins in …
ribosomal protein L13 (MRPL13) is responsible for synthesizing mitochondrial proteins in …
[HTML][HTML] Extracellular vesicle small RNA cargo discriminates non-cancer donors from pediatric B-lymphoblastic leukemia patients
MN Longjohn, JABJ Hudson, L Peña-Castillo… - Frontiers in …, 2023 - frontiersin.org
Pediatric B-acute lymphoblastic leukemia (B-ALL) is a disease of abnormally growing B
lymphoblasts. Here we hypothesized that extracellular vesicles (EVs), which are nanosized …
lymphoblasts. Here we hypothesized that extracellular vesicles (EVs), which are nanosized …