Liposome application: problems and prospects

Y Barenholz - Current opinion in colloid & interface science, 2001 - Elsevier
Liposomes are now in the marketplace as cosmeticeuticals and, more important,
pharmaceuticals. Three major achievements of liposome application: steric stabilization …

Biophysical aspects of using liposomes as delivery vehicles

AS Ulrich - Bioscience reports, 2002 - portlandpress.com
Liposomes are used as biocompatible carriers of drugs, peptides, proteins, plasmic DNA,
antisense oligonucleotides or ribozymes, for pharmaceutical, cosmetic, and biochemical …

Cationic lipids for gene delivery: Many players, one goal

F Ponti, M Campolungo, C Melchiori, N Bono… - Chemistry and physics …, 2021 - Elsevier
Lipid-based carriers represent the most widely used alternative to viral vectors for gene
expression and gene silencing purposes. This class of non-viral vectors is particularly …

Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes

N Maurer, KF Wong, H Stark, L Louie, D McIntosh… - Biophysical …, 2001 - cell.com
This study describes the effect of ethanol and the presence of poly (ethylene) glycol (PEG)
lipids on the interaction of nucleotide-based polyelectrolytes with cationic liposomes. It is …

DOTAP (and other cationic lipids): chemistry, biophysics, and transfection

D Simberg, S Weisman, Y Talmon… - Critical Reviews™ in …, 2004 - dl.begellhouse.com
Cationic lipid-mediated nucleic acid and protein delivery is becoming increasingly popular
for in vitro and in vivo applications. While the chemistry of cationic lipid carriers is moving …

Looking back, moving forward: Lipid nanoparticles as a promising frontier in gene delivery

D Pozzi, G Caracciolo - ACS Pharmacology & Translational …, 2023 - ACS Publications
Lipid nanoparticles (LNPs) have shown remarkable success in delivering genetic materials
like COVID-19 LNP vaccines, such as mRNA-1273/SpikeVax by Moderna and …

Thermodynamics of cationic lipid binding to DNA and DNA condensation: roles of electrostatics and hydrophobicity

D Matulis, I Rouzina, VA Bloomfield - Journal of the American …, 2002 - ACS Publications
Alkylammonium binding to DNA was studied by isothermal titration calorimetry.
Experimental data, obtained as functions of alkyl chain length, salt concentration, DNA …

Electrostatic interactions in biological DNA-related systems

AG Cherstvy - Physical Chemistry Chemical Physics, 2011 - pubs.rsc.org
In this perspective article, we focus on recent developments in the theory of charge effects in
biological DNA-related systems. The electrostatic effects on different levels of DNA …

Ion-specific hydration effects: Extending the Poisson-Boltzmann theory

D Ben-Yaakov, D Andelman, R Podgornik… - Current Opinion in …, 2011 - Elsevier
In aqueous solutions, dissolved ions interact strongly with the surrounding water and
surfaces, thereby modifying solution properties in an ion-specific manner. These ion …

Structural analysis of DNA complexation with cationic lipids

R Marty, CN N'soukpoé-Kossi… - Nucleic acids …, 2009 - academic.oup.com
Complexes of cationic liposomes with DNA are promising tools to deliver genetic information
into cells for gene therapy and vaccines. Electrostatic interaction is thought to be the major …