Importance of the pig as a human biomedical model

JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

Intermuscular adipose tissue in metabolic disease

BH Goodpaster, BC Bergman, AM Brennan… - Nature Reviews …, 2023 - nature.com
Intermuscular adipose tissue (IMAT) is a distinct adipose depot described in early reports as
a 'fatty replacement'or 'muscle fat infiltration'that was linked to ageing and neuromuscular …

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody …

TK Tan, P Rijal, R Rahikainen, AH Keeble… - Nature …, 2021 - nature.com
There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the
ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

[HTML][HTML] SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes

NSN Graham, C Junghans, R Downes, C Sendall… - Journal of Infection, 2020 - Elsevier
Summary Objectives To understand SARS-Co-V-2 infection and transmission in UK nursing
homes in order to develop preventive strategies for protecting the frail elderly residents …

Pig genome functional annotation enhances the biological interpretation of complex traits and human disease

Z Pan, Y Yao, H Yin, Z Cai, Y Wang, L Bai… - Nature …, 2021 - nature.com
The functional annotation of livestock genomes is crucial for understanding the molecular
mechanisms that underpin complex traits of economic importance, adaptive evolution and …

Understanding respiratory microbiome–immune system interactions in health and disease

SK Di Simone, I Rudloff, CA Nold-Petry… - Science translational …, 2023 - science.org
Interactions between the developing microbiome and maturing immune system in early life
are critical for establishment of a homeostasis beneficial to both host and commensals. The …

Natural and experimental SARS-CoV-2 infection in domestic and wild animals

DA Meekins, NN Gaudreault, JA Richt - Viruses, 2021 - mdpi.com
SARS-CoV-2 is the etiological agent responsible for the ongoing COVID-19 pandemic,
which continues to spread with devastating effects on global health and socioeconomics …

[HTML][HTML] The immunology of the porcine skin and its value as a model for human skin

A Summerfield, F Meurens, ME Ricklin - Molecular immunology, 2015 - Elsevier
The porcine skin has striking similarities to the human skin in terms of general structure,
thickness, hair follicle content, pigmentation, collagen and lipid composition. This has been …

Application areas of 3D bioprinting

IT Ozbolat, W Peng, V Ozbolat - Drug discovery today, 2016 - Elsevier
Highlights•Bioprinting is a powerful technology in tissue and organ fabrication.•Bioprinting
has gained significant interest in medicine and pharmaceutics.•Bioprinting has been widely …