C 2 H 2 zinc finger proteins probably comprise the largest family of regulatory proteins in
mammals. Most zinc fingers bind to a cognate DNA. In addition to DNA, many of the proteins …

Zinc regulates the gene expression machinery. It affects the structure of chromatin, the
template function of its DNA, the activity of numerous transcription factors and of RNA …

During development of the Drosophila wing, the decapentaplegic (dpp) gene is expressed
in a stripe of cells along the anteroposterior compartment boundary and gives rise to a …

The hematopoietic transcription factor GATA-1 is essential for development of the erythroid
and megakaryocytic lineages. Using the conserved zinc finger DNA-binding domain of …

Secreted signalling molecules provide cells with positional information that organizes long-
range pattern during the development of multicellular animals. Evidence is presented that …

Secreted morphogens such as the Drosophila TGF-β homolog Decapentaplegic (Dpp) are
thought to spread through target tissues and form long-range concentration gradients …

The secreted signaling protein Dpp acts as a morphogen to pattern the anterior–posterior
axis of the Drosophila wing. Dpp activity is required in all cells of the developing wing …

Abstract Townes-Brocks syndrome (IBS, OMIM# 107480) is a rare autosomal-dominant
malformation syndrome with a combination of anal, renal, limb and ear anomalies1 …

The tracheal (respiratory) system of Drosophila melanogaster is a branched network of
epithelial tubes that ramifies throughout the body and transports oxygen to the tissues. It …

SALL1 is a mammalian homolog of the Drosophila region-specific homeotic gene spalt (sal);
heterozygous mutations in SALL1 in humans lead to Townes-Brocks syndrome. We have …