Vitamin D3 (VD) is a secosteroid hormone and shows a pleiotropic effect in brain-related
disorders where it regulates redox imbalance, inflammation, apoptosis, energy production …

The central nervous system (CNS) has been considered an immunologically privileged site.
In the past few decades, research on inflammation in CNS diseases has mostly focused on …

Introduction 3-NP induction in rodent models has been shown to induce selective
neurodegeneration in the striatum followed by the cortex (Brouillet, 2014). However, it …

Many proteins in the immune system are also expressed in the brain. One such class of
immune proteins are T-cell receptors (TCRs), whose functions in T lymphocytes in adaptive …

Key points Protein kinases can modify the function of many proteins including ion channels.
However, the role of protein kinase A in modifying nicotinic receptors in the CNS has never …

The alpha7 nicotinic acetylcholine receptor (nAChR) has some peculiar kinetic properties.
From the literature of α7 nAChR-mediated currents we concluded that experimentally …

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutation in the X-linked
MECP2 gene. Random X-inactivation produces a mosaic of mutant (MT) and wild-type (WT) …

Background Resolving the kinetics of agonist binding events separately from the
subsequent channel gating processes requires the ability of applying and removing the …

Fast solution exchange techniques have revolutionized the study of synaptic transmission
and promise to remain an important neuroscience research tool. Here we provide evidence …

Los canales iónicos son proteínas multiméricas que regulan el pasaje de iones a través de
la membrana celular acoplando su funcionamiento a factores externos como el voltaje de …