Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

AP Singh, A Biswas, A Shukla, P Maiti - Signal transduction and …, 2019 - nature.com
The application of nanomedicines is increasing rapidly with the promise of targeted and
efficient drug delivery. Nanomedicines address the shortcomings of conventional therapy, as …

Current and novel polymeric biomaterials for neural tissue engineering

R Boni, A Ali, A Shavandi, AN Clarkson - Journal of biomedical science, 2018 - Springer
The nervous system is a crucial component of the body and damages to this system, either
by of injury or disease, can result in serious or potentially lethal consequences. Restoring …

PLGA-based nanoparticles: an overview of biomedical applications

F Danhier, E Ansorena, JM Silva, R Coco… - Journal of controlled …, 2012 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) is one of the most successfully developed
biodegradable polymers. Among the different polymers developed to formulate polymeric …

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

SJ Allen, JJ Watson, DK Shoemark, NU Barua… - Pharmacology & …, 2013 - Elsevier
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …

Advances in Parkinson's disease: 200 years later

NLG Del Rey, A Quiroga-Varela, E Garbayo… - Frontiers in …, 2018 - frontiersin.org
When James Parkinson described the classical symptoms of the disease he could hardly
foresee the evolution of our understanding over the next two hundred years. Nowadays …

Biomaterials for promoting brain protection, repair and regeneration

G Orive, E Anitua, JL Pedraz, DF Emerich - Nature Reviews …, 2009 - nature.com
Biomaterials are likely to have an increasingly important role in the treatment of nervous
system disorders. Recently developed biomaterials can enable and augment the targeted …

Nanomedicine and drug delivery systems in cancer and regenerative medicine

E Garbayo, S Pascual‐Gil… - Wiley …, 2020 - Wiley Online Library
Nanomedicine and drug delivery technologies play a prominent role in modern medicine,
facilitating better treatments than conventional drugs. Nanomedicine is being increasingly …

Stem cell technology for neurodegenerative diseases

JS Lunn, SA Sakowski, J Hur… - Annals of neurology, 2011 - Wiley Online Library
Over the past 20 years, stem cell technologies have become an increasingly attractive
option to investigate and treat neurodegenerative diseases. In the current review, we …

Novel focused ultrasound gene therapy approach noninvasively restores dopaminergic neuron function in a rat Parkinson's disease model

BP Mead, N Kim, GW Miller, D Hodges… - Nano …, 2017 - ACS Publications
Therapies capable of decelerating, or perhaps even halting, neurodegeneration in
Parkinson's disease (PD) remain elusive. Clinical trials of PD gene therapy testing the …

Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai… - Journal of Controlled …, 2016 - Elsevier
Focused ultrasound (FUS)-induced with microbubbles (MBs) is a promising technique for
noninvasive opening of the blood-brain barrier (BBB) to allow targeted delivery of …