Background Social media tools have provided health researchers with the opportunity to
engage with communities and groups in a nonconventional manner to recruit participants for …

Clinical trials are time consuming, expensive, and often burdensome on patients. Clinical
trials can fail for many reasons. This survey reviews many of these reasons and offers …

High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …

Background The past decade has seen considerable interest in the development and
evaluation of complex interventions to improve health. Such interventions can only have a …

Importance The discontinuation of randomized clinical trials (RCTs) raises ethical concerns
and often wastes scarce research resources. The epidemiology of discontinued RCTs …

Background A commonly reported problem with the conduct of multicentre randomised
controlled trials (RCTs) is that recruitment is often slower or more difficult than expected, with …

Background Pragmatic randomised controlled trials (RCTs) are considered essential to
determine effective interventions for routine clinical practice, but many fail to recruit …

Background Poor recruitment to randomised controlled trials (RCTs) is a widespread
problem. Provision of interventions aimed at supporting or incentivising clinicians may …

After identification of an important research question and selection of an appropriate study
design, waste can arise from the regulation, governance, and management of biomedical …

Background Recruiting participants into clinical trials continues to be a challenge, which can
result in study delay or termination. Recent studies have used social media to enhance …