Integrin inactivators: balancing cellular functions in vitro and in vivo

D Bouvard, J Pouwels, N De Franceschi… - Nature reviews Molecular …, 2013 - nature.com
Integrins mediate cell–matrix and cell–cell interactions and integrate extracellular cues to
the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is …

The dual role of filamin A in cancer: can't live with (too much of) it, can't live without it

RM Savoy, PM Ghosh - Endocrine-related cancer, 2013 - erc.bioscientifica.com
Filamin A (FlnA) has been associated with actin as cytoskeleton regulator. Recently its role
in the cell has come under scrutiny for FlnA's involvement in cancer development. FlnA was …

The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation

GK Pandey, S Mitra, S Subhash, F Hertwig, M Kanduri… - Cancer cell, 2014 - cell.com
Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most
common extracranial tumor of childhood. By sequencing transcriptomes of low-and high-risk …

Dissecting the expression landscape of RNA-binding proteins in human cancers

B Kechavarzi, SC Janga - Genome biology, 2014 - Springer
Background RNA-binding proteins (RBPs) play important roles in cellular homeostasis by
controlling gene expression at the post-transcriptional level. Results We explore the …

The function and pathogenic mechanism of filamin A

J Zhou, X Kang, H An, Y Lv, X Liu - Gene, 2021 - Elsevier
Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the
cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …

Upregulated cytoskeletal proteins promote pathological angiogenesis in moyamoya disease

S He, J Zhang, Z Liu, Y Wang, X Hao, X Wang, Z Zhou… - Stroke, 2023 - Am Heart Assoc
BACKGROUND: Moyamoya disease (MMD) is a rare progressive vascular disease that
leads to intracranial internal carotid artery stenosis and eventual occlusion. However, its …

Filamin A regulates cardiovascular remodeling

S Bandaru, C Ala, AX Zhou, LM Akyürek - International journal of …, 2021 - mdpi.com
Filamin A (FLNA) is a large actin-binding cytoskeletal protein that is important for cell motility
by stabilizing actin networks and integrating them with cell membranes. Interestingly, a C …

Complex roles of filamin-A mediated cytoskeleton network in cancer progression

J Yue, S Huhn, Z Shen - Cell & bioscience, 2013 - Springer
Abstract Filamin-A (FLNA), also called actin-binding protein 280 (ABP-280), was originally
identified as a non-muscle actin binding protein, which organizes filamentous actin into …

Exploration of oxygen-induced retinopathy model to discover new therapeutic drug targets in retinopathies

M Vähätupa, TAH Järvinen… - Frontiers in …, 2020 - frontiersin.org
Oxygen-induced retinopathy (OIR) is a pure hypoxia-driven angiogenesis model and the
most widely used model for ischemic retinopathies, such as retinopathy of prematurity …

Filamin A: insights into its exact role in cancers

QQ Shao, TP Zhang, WJ Zhao, ZW Liu, L You… - Pathology & Oncology …, 2016 - Springer
Filamin A (FlnA) is a well-known actin cross-linking protein. It serves as a scaffold for over 90
binding partners and involves in multiple cell functions, of which cell migration and adhesion …