The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Under normal conditions, food intake and energy expenditure are balanced by a
homeostatic system that maintains stability of body fat content over time. However, this …

The global rise in the prevalence of obesity and associated co-morbidities such as type 2
diabetes, cardiovascular disease, and cancer represents a major public health concern. The …

Oxytocin (OT) and vasopressin (VP) are two closely related neuropeptides, widely known for
their peripheral hormonal effects. Specific receptors have also been found in the brain …

Oxytocin (Oxt) is a nonapeptide hormone best known for its role in lactation and parturition.
Since 1906 when its uterine-contracting properties were described until 50 years later when …

One of the most challenging problems facing modern medicine is how to deliver a given
drug to a specific target at the exclusion of other regions. For example, a variety of …

An inverse relationship between brain serotonin and food intake and body weight has been
known for more than 30years. Specifically, augmentation of brain serotonin inhibits food …

Objective Preclinical studies indicate that oxytocin is anorexigenic and has beneficial
metabolic effects. Oxytocin effects on nutrition and metabolism in humans are not well …

Experiments in animals suggest that the neuropeptide oxytocin acts as an anorexigenic
signal in the central nervous control of food intake. In humans, however, research has …