The use of laboratory animals is critical to the discovery and in vivo pre-clinical testing of
new drugs and drug combinations for use in humans. M. tuberculosis infection of mice, rats …

Research for a novel vaccine to prevent tuberculosis is an urgent medical need. The current
vaccine, BCG, has demonstrated a non-homogenous efficacy in humans, but still is the gold …

C3HeB/FeJ mice infected with Mycobacterium tuberculosis were used in an experimental
animal model mimicking active tuberculosis in humans to evaluate the effect of …

As anyone who has attended tuberculosis research meeting in recent years can attest,
disputes about validity of experimental animal models of tuberculosis (TB) erupt frequently …

The chronic phase of Mycobacterium tuberculosis infection in mouse experimental models is
characterized by the accumulation of foamy macrophages (FM)–which shape the outer ring …

Science has been taking profit from animal models since the first translational experiments
back in ancient Greece. From there, and across all history, several remarkable findings have …

ABSTRACT RUTI is a therapeutic vaccine that is generated from detoxified and liposomed
Mycobacterium tuberculosis cell fragments that has demonstrated its efficacy in the control of …

Liquefaction is one of the most intriguing aspects of human tuberculosis. It is a major cause
of the transition from the infection to active disease (tuberculosis, TB) as well as the …

Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), which mainly causes
pulmonary injury and tubercles. Although macrophages are generally considered to harbor …

The mechanisms leading to granuloma caseation, a hallmark of tuberculosis (TB) in
humans, are poorly understood. Lung histopathology of C57BL/6 (WT) mice 16 weeks after …