An RNA-centric view of transcription and genome organization
JE Henninger, RA Young - Molecular Cell, 2024 - cell.com
Foundational models of transcriptional regulation involve the assembly of protein complexes
at DNA elements associated with specific genes. These assemblies, which can include …
at DNA elements associated with specific genes. These assemblies, which can include …
Interplay of dynamic genome organization and biomolecular condensates
After 60 years of chromatin investigation, our understanding of chromatin organization has
evolved from static chromatin fibers to dynamic nuclear compartmentalization. Chromatin is …
evolved from static chromatin fibers to dynamic nuclear compartmentalization. Chromatin is …
[HTML][HTML] Condensate interfaces can accelerate protein aggregation
Protein aggregates, formed from the assembly of aberrant, misfolded proteins, are a
hallmark of neurodegenerative diseases. Disease-associated aggregates such as mutant …
hallmark of neurodegenerative diseases. Disease-associated aggregates such as mutant …
Approaches to characterize chromatin subcompartment organization in the cell nucleus
The mechanism of self-organization of chromatin subcompartments on the 0.1–1 μm scale
and their impact on genome-associated activities has long been a key aspect of research on …
and their impact on genome-associated activities has long been a key aspect of research on …
Biomolecular condensates: A new lens on cancer biology
Cells are compartmentalized into different organelles to ensure precise spatial temporal
control and efficient operation of cellular processes. Membraneless organelles, also known …
control and efficient operation of cellular processes. Membraneless organelles, also known …
Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus
Abnormal cell nuclear shapes are hallmarks of diseases, including progeria, muscular
dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin …
dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin …
Deciphering the molecular mechanism underlying morphology transition in two-component DNA-protein cophase separation
Nucleic acid and protein co-condensates exhibit diverse morphologies crucial for
fundamental cellular processes. Despite their significance, the molecular mechanisms …
fundamental cellular processes. Despite their significance, the molecular mechanisms …