Nucleic acid ligands with protein-like side chains: modified aptamers and their use as diagnostic and therapeutic agents
JC Rohloff, AD Gelinas, TC Jarvis, UA Ochsner… - … Therapy-Nucleic Acids, 2014 - cell.com
Limited chemical diversity of nucleic acid libraries has long been suspected to be a major
constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by …
constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by …
Expression of recombinant antibodies
A Frenzel, M Hust, T Schirrmann - Frontiers in immunology, 2013 - frontiersin.org
Recombinant antibodies are highly specific detection probes in research, diagnostics, and
have emerged over the last two decades as the fastest growing class of therapeutic proteins …
have emerged over the last two decades as the fastest growing class of therapeutic proteins …
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans
Nutrition has broad impacts on all physiological processes. However, how nutrition affects
human immunity remains largely unknown. Here we explored the impact of a dietary …
human immunity remains largely unknown. Here we explored the impact of a dietary …
Development and validation of a protein-based risk score for cardiovascular outcomes among patients with stable coronary heart disease
Importance Precise stratification of cardiovascular risk in patients with coronary heart
disease (CHD) is needed to inform treatment decisions. Objective To derive and validate a …
disease (CHD) is needed to inform treatment decisions. Objective To derive and validate a …
From the RNA world to the clinic
BA Sullenger, S Nair - Science, 2016 - science.org
The study of RNA has continually emphasized the structural and functional versatility of RNA
molecules. This versatility has inspired translational and clinical researchers to explore the …
molecules. This versatility has inspired translational and clinical researchers to explore the …
Oncogenic protein interfaces: small molecules, big challenges
Historically, targeting protein–protein interactions with small molecules was not thought
possible because the corresponding interfaces were considered mostly flat and featureless …
possible because the corresponding interfaces were considered mostly flat and featureless …
The molecular basis of predicting atherosclerotic cardiovascular disease risk
M Nayor, KJ Brown, RS Vasan - Circulation research, 2021 - Am Heart Assoc
Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages:
initiation, progression (or regression), and complications. By integrating known biology …
initiation, progression (or regression), and complications. By integrating known biology …
Clinical application of kidney biomarkers in cirrhosis
AS Allegretti, E Solà, P Ginès - American Journal of Kidney Diseases, 2020 - Elsevier
Acute kidney injury (AKI) is one of the most common and morbid complications of
decompensated cirrhosis. Management of AKI is dictated by cause: prerenal AKI is treated …
decompensated cirrhosis. Management of AKI is dictated by cause: prerenal AKI is treated …
Defining the serum proteomic signature of hepatic steatosis, inflammation, ballooning and fibrosis in non-alcoholic fatty liver disease
Background & Aims Despite recent progress, non-invasive tests for the diagnostic
assessment and monitoring of non-alcoholic fatty liver disease (NAFLD) remain an unmet …
assessment and monitoring of non-alcoholic fatty liver disease (NAFLD) remain an unmet …
Uncovering the depths of the human proteome: antibody-based technologies for ultrasensitive multiplexed protein detection and quantification
AH Ren, EP Diamandis, V Kulasingam - Molecular & Cellular Proteomics, 2021 - ASBMB
Probing the human proteome in tissues and biofluids such as plasma is attractive for
biomarker and drug target discovery. Recent breakthroughs in multiplex, antibody-based …
biomarker and drug target discovery. Recent breakthroughs in multiplex, antibody-based …