The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …

Transient receptor potential (TRP) channels are a large, eukaryotic ion channel superfamily
that control diverse physiological functions, and therefore are attractive drug targets,,,–. More …

Numerous physiological functions rely on distinguishing temperature through temperature-
sensitive transient receptor potential channels (thermo-TRPs). Although the function of …

INTRODUCTION Transient receptor potential melastatin member 8 (TRPM8) is a calcium-
permeable ion channel that serves as the principal detector of cold in humans. Natural and …

The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular
transducer responsible for the cool sensation elicited by menthol and cold in mammals …

Transient receptor potential vanilloid 2 (TRPV2) plays a critical role in neuronal
development, cardiac function, immunity, and cancer. Cannabidiol (CBD), the non …

Transient receptor potential vanilloid 2 (TRPV2) is involved in many critical physiological
and pathophysiological processes, making it a promising drug target. Here we present cryo …

Transient receptor potential (TRP) channels are polymodal molecular sensors involved in
numerous physiological processes and implicated in a variety of human diseases. Several …