Polyconjugates for in vivo delivery of polynucleotides
DB Rozema, JE Hagstrom, J Klein, DL Lewis… - US Patent …, 2012 - Google Patents
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Lollo et al. 5,994,517 A 11/1999 Ts'o et al. 6,020,457 A 2/2000 Klimash et al. 6,300,317 B1 …
Lollo et al. 5,994,517 A 11/1999 Ts'o et al. 6,020,457 A 2/2000 Klimash et al. 6,300,317 B1 …
Compositions for targeted delivery of siRNA
DB Rozema, DL Lewis, DH Wakefield - US Patent 8,313,772, 2012 - Google Patents
The present invention is directed compositions for targeted delivery of RNA interference
(RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are …
(RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are …
Reduced size self-delivering RNAi compounds
A Khvorova, W Salomon, J Kamens… - US Patent …, 2018 - Google Patents
2013-06-19 Assigned to RXI PHARMACEUTICALS CORPORATION reassignment RXI
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Reduced size self-delivering RNAi compounds
A Khvorova, W Salomon, J Kamens… - US Patent …, 2014 - Google Patents
2013-01-11 Assigned to RXI PHARMACEUTICALS CORPORATION reassignment RXI
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PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
Aptamer regulated nucleic acids and uses thereof
US9315862B2 - Aptamer regulated nucleic acids and uses thereof - Google Patents
US9315862B2 - Aptamer regulated nucleic acids and uses thereof - Google Patents Aptamer …
US9315862B2 - Aptamer regulated nucleic acids and uses thereof - Google Patents Aptamer …
Signal activated RNA interference
SP Han, RD Barish, WA Goddard III - US Patent 9,029,524, 2015 - Google Patents
2009-07-15 Assigned to CALIFORNIA INSTITUTE OF TECHNOLOGY reassignment
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Reduced size self-delivering RNAi compounds
A Khvorova, W Salomon, J Kamens… - US Patent …, 2015 - Google Patents
The present invention relates to RNAi constructs with minimal double-stranded regions, and
their use in gene silencing. RNAi constructs associated with the invention include a double …
their use in gene silencing. RNAi constructs associated with the invention include a double …
Reduced size self-delivering RNAi compounds
A Khvorova, W Salomon, J Kamens… - US Patent …, 2015 - Google Patents
2013-06-17 Assigned to RXI PHARMACEUTICALS CORPORATION reassignment RXI
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Phagocytic cell delivery of RNAI
D Samarsky, TM Woolf - US Patent 8,815,818, 2014 - Google Patents
The present invention provides a particulate delivery system for delivering an RNAi construct
to phagocytic cells such as macrophages, comprising various con? gurations of a com plex …
to phagocytic cells such as macrophages, comprising various con? gurations of a com plex …
RNA interference in dermal and fibrotic indications
A Khvorova, W Salomon, J Kamens… - US Patent …, 2016 - Google Patents
2013-10-31 Assigned to RXI PHARMACEUTICALS CORPORATION reassignment RXI
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PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …