[HTML][HTML] Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses
DM Morens, JK Taubenberger, AS Fauci - Cell host & microbe, 2023 - cell.com
Viruses that replicate in the human respiratory mucosa without infecting systemically,
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …
SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates
GA Poland, IG Ovsyannikova, RB Kennedy - The Lancet, 2020 - thelancet.com
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 is
crucial to understanding disease pathogenesis and the usefulness of bridge therapies, such …
crucial to understanding disease pathogenesis and the usefulness of bridge therapies, such …
Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …
COVID-19 vaccines administered intramuscularly and designed to only target the spike …
Immunological considerations for COVID-19 vaccine strategies
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
Immune evasion of SARS-CoV-2 emerging variants: what have we learnt so far?
I Lazarevic, V Pravica, D Miljanovic, M Cupic - Viruses, 2021 - mdpi.com
Despite the slow evolutionary rate of SARS-CoV-2 relative to other RNA viruses, its massive
and rapid transmission during the COVID-19 pandemic has enabled it to acquire significant …
and rapid transmission during the COVID-19 pandemic has enabled it to acquire significant …
Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters
L Zhang, Y Jiang, J He, J Chen, R Qi, L Yuan… - Nature …, 2023 - nature.com
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
and “anatomical escape” characteristics threaten the effectiveness of current coronavirus …
and “anatomical escape” characteristics threaten the effectiveness of current coronavirus …
Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis
Aside from centrally induced trained immunity in the bone marrow (BM) and peripheral
blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate …
blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate …
[HTML][HTML] Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans
M Jeyanathan, DK Fritz, S Afkhami, E Aguirre… - JCI insight, 2022 - ncbi.nlm.nih.gov
Background Adenovirus-vectored (Ad-vectored) vaccines are typically administered via im
injection to humans and are incapable of inducing respiratory mucosal immunity. However …
injection to humans and are incapable of inducing respiratory mucosal immunity. However …
Optimize prime/boost vaccine strategies: trained immunity as a new player in the game
JL Palgen, Y Feraoun, G Dzangué-Tchoupou… - Frontiers in …, 2021 - frontiersin.org
Most vaccines require multiple doses to induce long-lasting protective immunity in a high
frequency of vaccines, and to ensure strong both individual and herd immunity. Repetitive …
frequency of vaccines, and to ensure strong both individual and herd immunity. Repetitive …
Innate immune signaling and proteolytic pathways in the resolution or exacerbation of SARS-CoV-2 in Covid-19: key therapeutic targets?
JM Sallenave, L Guillot - Frontiers in immunology, 2020 - frontiersin.org
COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-
2, an enveloped virus with a positive-polarity, single-stranded RNA genome. The initial …
2, an enveloped virus with a positive-polarity, single-stranded RNA genome. The initial …