Modulation of the renin-angiotensin-aldosterone system is a foundation of therapy for
cardiovascular and kidney diseases. Excess aldosterone plays an important role in …

Congenital forms of endocrine hypertension are rare and potentially life-threatening
disorders, primarily caused by genetic defects affecting adrenal steroid synthesis and …

The purpose of this study was to determine the long-term pattern of plasma aldosterone
concentration (PAC) trajectories and to explore the relationship between PAC trajectory …

Activation of the renin–angiotensin–aldosterone system (RAAS) plays an important
pathophysiological role in hypertension. Increased mRNA levels of the angiotensinogen …

Hypertension (HTN) affects more than 30% of adults worldwide. It is the most frequent
modifiable cardiovascular (CV) risk factor, and is responsible for more than 10 million death …

As growing evidence implicates extrarenal mineralocorticoid receptor (MR) in
cardiovascular disease (CVD), recent studies have defined both cell-and sex-specific roles …

Systemic hypertension remains one of the leading cause of morbidity and mortality in the
United States and throughout the world. Baxdrostat (CIN-107), a new drug developed by …

Aldosterone is a steroid hormone that primarily acts through activation of the
mineralocorticoid receptor (MR), a nuclear receptor responsible for downstream genomic …

Background Hyperaldosteronism is an endocrine disorder leading to persistent and severe
hypertension. G protein-coupled estrogen receptor 1 (GPER1) is regarded as a potential …

Introduction Tetrandrine (Tet) is the main pharmacological component of Stephania
tetrandra S. Moore, which is a well-documented traditional Chinese medicine known for its …