Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all
BA Desimmie, KA Delviks-Frankenberrry… - Journal of molecular …, 2014 - Elsevier
Several members of the APOBEC3 family of cellular restriction factors provide intrinsic
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
Functions and malfunctions of mammalian DNA-cytosine deaminases
The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils,
causing base substitutions and strand breaks. They are induced by cytokines produced …
causing base substitutions and strand breaks. They are induced by cytokines produced …
APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis
Despite efforts in understanding its underlying mechanisms, the etiology of chromosomal
instability (CIN) remains unclear for many tumor types. Here, we identify CIN initiation as a …
instability (CIN) remains unclear for many tumor types. Here, we identify CIN initiation as a …
Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase
F Ito, AL Alvarez-Cabrera, S Liu, H Yang… - Science …, 2023 - science.org
Human APOBEC3G (A3G) is a virus restriction factor that inhibits HIV-1 replication and
triggers lethal hypermutation on viral reverse transcripts. HIV-1 viral infectivity factor (Vif) …
triggers lethal hypermutation on viral reverse transcripts. HIV-1 viral infectivity factor (Vif) …
APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection
L Manjunath, S Oh, P Ortega, A Bouin… - Nature …, 2023 - nature.com
Double-stranded RNA produced during viral replication and transcription activates both
protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression …
protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression …
Suppression of APOBEC3-mediated restriction of HIV-1 by Vif
The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme
S Sharma, SK Patnaik, RT Taggart, BE Baysal - Scientific reports, 2016 - nature.com
APOBEC3G is a cytidine deaminase with two homologous domains and restricts
retroelements and HIV-1. APOBEC3G deaminates single-stranded DNAs via its C-terminal …
retroelements and HIV-1. APOBEC3G deaminates single-stranded DNAs via its C-terminal …
The role of APOBECs in viral replication
WK Xu, H Byun, JP Dudley - Microorganisms, 2020 - mdpi.com
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) proteins are a
diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of …
diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of …
Modeling the embrace of a mutator: APOBEC selection of nucleic acid ligands
JD Salter, HC Smith - Trends in Biochemical Sciences, 2018 - cell.com
The 11-member APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family
of zinc-dependent cytidine deaminases bind to RNA and single-stranded DNA (ssDNA) and …
of zinc-dependent cytidine deaminases bind to RNA and single-stranded DNA (ssDNA) and …
Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G
H Yang, K Kim, S Li, J Pacheco, XS Chen - Nature Communications, 2022 - nature.com
An essential step in restricting HIV infectivity by the antiviral factor APOBEC3G is its
incorporation into progeny virions via binding to HIV RNA. However, the mechanism of …
incorporation into progeny virions via binding to HIV RNA. However, the mechanism of …