Triple-negative breast cancer (TNBC) is associated with an increased risk of early
recurrence and distant metastasis, as well as the development of therapeutic resistance and …

Circulating tumor cells (CTCs) are a major contributor of cancer metastases and hold a
promising prognostic significance in cancer detection. Performing functional and molecular …

Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality
by malignancy in women and represents a main problem for public health worldwide. Tumor …

Abstract RANKL/RANK/OPG system consists of three essential signaling molecules: i) the
receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF …

The activation of nuclear factor-kappaB (NFΚB), a proinflammatory transcription factor, is a
commonly observed phenomenon in breast cancer. It facilitates the development of a …

Simple Summary Breast cancer remains the most commonly diagnosed cancer and the
leading cause of cancer death among females worldwide. It is a highly heterogeneous …

Targeting of the protein degradation pathway, in particular, the ubiquitin-proteasome system,
has emerged as an attractive novel cancer chemotherapeutic modality. Although …

Despite significant advances in cancer diagnostics and therapeutics the majority of cancer
unfortunately remains incurable, which has led to continued research to better understand …

The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic
molecules that regulate the expression of more than 150 genes involved in a broad range of …

TNBC (Triple Negative Breast Cancer) is a subtype of breast cancer with an aggressive
phenotype which shows high metastatic capability and poor prognosis. Owing to its intrinsic …