The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

The gonadotropin-releasing hormone (GnRH) neuronal network generates pulse and surge
modes of gonadotropin secretion critical for puberty and fertility. The arcuate nucleus …

BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably
soy. A litany of health benefits including a lowered risk of osteoporosis, heart disease, breast …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

Maturation of the reproductive system during puberty results in elevated levels of gonadal
steroid hormones. These hormones sculpt neural circuits during adolescence, a time of …

We examined the role of kisspeptin and its receptor, the G-protein-coupled receptor GPR54,
in governing the onset of puberty in the mouse. In the adult male and female mouse …

The neuropeptide kisspeptin has recently been implicated as having a critical role in the
activation of the GnRH neurons to bring about puberty. We examined here the postnatal …

Gonadotropin-dependent, or central, precocious puberty is caused by early maturation of the
hypothalamic–pituitary–gonadal axis. In girls, this condition is most often idiopathic …