Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors

M Gümüş, ŞN Babacan, Y Demir, Y Sert… - Archiv Der …, 2022 - Wiley Online Library
Human carbonic anhydrase (hCA) isoenzymes are zinc ion‐containing, widespread
metalloenzymes and they classically play a role in pH homeostasis maintenance. CA …

Determination of Antioxidant, Anti-Alzheimer, Antidiabetic, Antiglaucoma and Antimicrobial Effects of Zivzik Pomegranate (Punica granatum)—A Chemical Profiling by …

H Karagecili, E İzol, E Kirecci, İ Gulcin - Life, 2023 - mdpi.com
Zivzik pomegranate (Punica granatum) has recently sparked considerable interest due to its
nutritional and antioxidant properties. To evaluate the antioxidant capacities of P. granatum …

[HTML][HTML] Synthesis and inhibition profiles of N-benzyl-and N-allyl aniline derivatives against carbonic anhydrase and acetylcholinesterase–A molecular docking study

I Mahmudov, Y Demir, Y Sert, Y Abdullayev… - Arabian Journal of …, 2022 - Elsevier
The alkyl and aryl derivatives of aniline are important starting materials in fine organic
synthesis. Allyl bromide and benzyl chloride were taken as substrates for the alkylation …

Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma …

M Mutlu, Z Bingol, EM Uc, E Köksal, AC Goren… - Life, 2023 - mdpi.com
In this study, for the first time, the antioxidant and antidiabetic properties of the essential oil
from cinnamon (Cinnamomum zeylanicum) leaves were evaluated and investigated using …

Evaluation of the in vitro antioxidant, antidiabetic and anticholinergic properties of rosmarinic acid from rosemary (Rosmarinus officinalis L.)

M Topal, İ Gulcin - Biocatalysis and Agricultural Biotechnology, 2022 - Elsevier
In this study, antidiabetic, anticholinergic, and antioxidant abilities of rosmarinic acid were
evaluated and compared to standards. To determine its antioxidant activity different in vitro …

Antioxidant, antidiabetic, anticholinergic, and antiglaucoma effects of magnofluorine

L Durmaz, H Kiziltas, L Guven, H Karagecili, S Alwasel… - Molecules, 2022 - mdpi.com
Magnofluorine, a secondary metabolite commonly found in various plants, has
pharmacological potential; however, its antioxidant and enzyme inhibition effects have not …

Screening of carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzyme inhibition effects and antioxidant activity of coumestrol

L Durmaz, A Erturk, M Akyüz, L Polat Kose, EM Uc… - Molecules, 2022 - mdpi.com
Coumestrol (3, 9-dihydroxy-6-benzofuran [3, 2-c] chromenone) as a phytoestrogen and
polyphenolic compound is a member of the Coumestans family and is quite common in …

Isofraxidin: Antioxidant, Anti‐carbonic Anhydrase, Anti‐cholinesterase, Anti‐diabetic, and in Silico Properties

L Durmaz, İ Gulçin, P Taslimi, B Tüzün - ChemistrySelect, 2023 - Wiley Online Library
The development of innovative pharmacological formulations for the treatment and
prevention of various major diseases, including cancer, diabetes, and glaucoma, has been …

Synthesis and Evaluation of Quinazolin‐4(3H)‐one Derivatives as Multitarget Metabolic Enzyme Inhibitors: A Biochemistry‐Oriented Drug Design

FS Tokalı, P Taslimi, M Sadeghi, H Şenol - ChemistrySelect, 2023 - Wiley Online Library
In this study, imines bearing quinazolin‐4 (3H)‐one were synthesized and their inhibitory
properties were investigated against some metabolic enzymes including …

Synthesis of new carboxylates and sulfonates containing thiazolidin-4-one ring and evaluation of inhibitory properties against some metabolic enzymes

FS Tokalı, P Taslimi, B Tüzün, A Karakuş… - Journal of the Iranian …, 2023 - Springer
A series of thizaolidin-4-one derivatives (3a-o) was synthesized with excellent yield (94–
97%) and the structures of the compounds were characterized with Fourier-transform …