Physiological substrates of cAMP-dependent protein kinase

JB Shabb - Chemical reviews, 2001 - ACS Publications
The purpose of this review is to provide an account of the physiological substrates of cAMP-
dependent protein kinase (PKA). Discussion is limited to just over 100 unique gene products …

Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?

A Laurenza, EMH Sutkowski, KB Seamon - Trends in pharmacological …, 1989 - cell.com
Forskolin, a naturally occurring diterpene, directly stimulates adenylyl cyclaseand has been
used extensively to increase CAMP and to elicit CAMP-dependent physiological responses …

Effect of Forskolin on Voltage-Gated K+ Channels Is Independent of Adenylate Cyclase Activation

T Hoshi, SS Garber, RW Aldrich - Science, 1988 - science.org
Forskolin is commonly used to stimulate adenylate cyclase in the study of modulation of ion
channels and other proteins by adenosine 3′, 5′-monophosphate (cAMP)-dependent …

Activators of protein kinase C enhance acetylcholine receptor desensitization in sympathetic ganglion neurons.

JE Downing, LW Role - Proceedings of the National …, 1987 - National Acad Sciences
Recent studies suggest that phosphorylation may regulate the rate of desensitization of
nicotinic acetylcholine (AcCho) receptors (AcChoR) in vertebrate muscle and Torpedo. It is …

Modulation of acetylcholine receptor desensitization by forskolin is independent of cAMP

PK Wagoner, BS Pallotta - Science, 1988 - science.org
Biochemical and electrophysiological studies suggest that adenosine 3′, 5′-
monophosphate (cAMP)-dependent phosphorylation of the nicotinic acetylcholine receptor …

Calcitonin gene-related peptide regulates phosphorylation of the nicotinic acetylcholine receptor in rat myotubes

K Miles, P Greengard, RL Huganir - Neuron, 1989 - cell.com
The nicotinic acetylcholine receptor(AChR) is a substrate for at least three different protein
kinases, and phosphorylation of the receptor has been shown to increase its rate of …

cAMP and forskolin decrease gamma-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes.

G Heuschneider, RD Schwartz - Proceedings of the …, 1989 - National Acad Sciences
The effects of the cyclic nucleotide cAMP on gamma-aminobutyric acid-gated chloride
channel function were investigated. The membrane-permeant cAMP analog N6, O2' …

Cyclic AMP regulates the proportion of functional acetylcholine receptors on chicken ciliary ganglion neurons.

JF Margiotta, DK Berg… - Proceedings of the …, 1987 - National Acad Sciences
Previous studies have shown that the number of functional acetylcholine receptors
(AcChoRs) on chicken ciliary ganglion neurons in culture is considerably smaller than the …

Adenosine receptors activate adenylate cyclase and enhance secretion from bovine adrenal chromaffin cells in the presence of forskolin

YJ Chern, KT Kim, LL Slakey… - Journal of …, 1988 - Wiley Online Library
Cells of the adrenal medulla release not only catecholamines but also high concentrations
of neuropeptides and nucleotides. Chromaffin cells, like many neuronal cells, have a …

Desensitization of the acetylcholine receptor of frog end‐plates measured in a Vaseline‐gap voltage clamp.

AB Cachelin, D Colquhoun - The Journal of physiology, 1989 - Wiley Online Library
1. Desensitization of the nicotinic acetylcholine receptor of the frog end‐plate was
investigated in dissociated frog muscle fibres using the Vaseline‐gap clamp method so that …