Organoselenium compounds have found such wide utility because of their effects on an
extraordinary number of very different reactions, including many carbon-carbon bond …

The advance in the area of synthesis and reactivity of organoselenium, as well as the
discovery that selenium was the cause of severe intoxication episodes of livestock in the …

Neurological disorders are common, costly, and can cause enduring disability. Although
mostly unknown, a few environmental toxicants are recognized causes of neurological …

Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase
family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major …

Methylmercury (MeHg) is an environmental toxicant that leads to long-lasting neurological
and developmental deficits in animals and humans. Although the molecular mechanisms …

Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …

A novel series of compounds obtained by fusing the cholinesterase inhibitor donepezil and
the antioxidant ebselen were designed as multi-target-directed ligands against Alzheimer's …

Small molecule probes are indispensable tools to explore diverse cellular events. However,
finding a specific probe of a target remains a high challenge. Here we report the discovery of …

Oxidative stress caused by reactive species, including reactive oxygen species, reactive
nitrogen species, and unbound, adventitious metal ions (eg, iron [Fe] and copper [Cu]), is an …

Ebselen is a synthetic organoselenium radical scavenger compound that possesses
glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols …