Thiazole ring—A biologically active scaffold
A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …
applications. Its derivatives have a wide range of biological activities such as antioxidant …
Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity
Due to the increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to
conventional antibiotics, further efforts are needed to develop new antimicrobial agents …
conventional antibiotics, further efforts are needed to develop new antimicrobial agents …
Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators
VN Uversky - Frontiers in Molecular Biosciences, 2014 - frontiersin.org
Biologically active proteins without stable tertiary structure are common in all known
proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to …
proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to …
[HTML][HTML] Beyond synthetic lethality: charting the landscape of pairwise gene expression states associated with survival in cancer
The phenotypic effect of perturbing a gene's activity depends on the activity level of other
genes, reflecting the notion that phenotypes are emergent properties of a network of …
genes, reflecting the notion that phenotypes are emergent properties of a network of …
Synthesis, molecular docking and QSAR studies of 2, 4-disubstituted thiazoles as antimicrobial agents
In present study a series of 2, 4-disubstituted thiazole derivatives was synthesized and
evaluated for their in vitro antibacterial and antifungal activities against B. subtilis, E. coli, S …
evaluated for their in vitro antibacterial and antifungal activities against B. subtilis, E. coli, S …
PUF60 accelerates the progression of breast cancer through downregulation of PTEN expression
D Sun, W Lei, X Hou, H Li, W Ni - Cancer management and …, 2019 - Taylor & Francis
Background PUF60 is a splicing variant of far upstream element binding protein 1-
interacting repressor, which is abnormally expressed in a variety of tumors and is closely …
interacting repressor, which is abnormally expressed in a variety of tumors and is closely …
[HTML][HTML] Identification of specific and common diagnostic antibody markers for gastrointestinal cancers by SEREX screening using testis cDNA phage library
S Kobayashi, T Hiwasa, T Arasawa, A Kagaya, S Ishii… - Oncotarget, 2018 - ncbi.nlm.nih.gov
The present study was planned to identify novel serum antibody markers for digestive organ
cancers. We have used screening by phage expression cloning and identified novel …
cancers. We have used screening by phage expression cloning and identified novel …
[HTML][HTML] Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients
S Kobayashi, T Hoshino, T Hiwasa, M Satoh… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Anti-PUF60, poly (U)-binding-splicing factor, autoantibodies are reported to be
detected in the sera of dermatomyositis and Sjogren's syndrome that occasionally …
detected in the sera of dermatomyositis and Sjogren's syndrome that occasionally …
The involvement of c-Myc in the DNA double-strand break repair via regulating radiation-induced phosphorylation of ATM and DNA-PKcs activity
F Cui, R Fan, Q Chen, Y He, M Song, Z Shang… - Molecular and cellular …, 2015 - Springer
Deregulation of c-Myc often occurs in various human cancers, which not only contributes to
the genesis and progression of cancers but also affects the outcomes of cancer radio-or …
the genesis and progression of cancers but also affects the outcomes of cancer radio-or …