Systemic lupus erythematosus in children and young people
Abstract Purpose of Review Juvenile-onset systemic lupus erythematosus ((j) SLE) is an
autoimmune/inflammatory disease that results in significant damage and disability. When …
autoimmune/inflammatory disease that results in significant damage and disability. When …
Systemic lupus erythematosus and deficiencies of early components of the complement classical pathway
ACL Macedo, L Isaac - Frontiers in immunology, 2016 - frontiersin.org
The complement system plays an important role in the innate and acquired immune
response against pathogens. It consists of more than 30 proteins found in soluble form or …
response against pathogens. It consists of more than 30 proteins found in soluble form or …
The Ehlers–Danlos syndromes, rare types
AF Brady, S Demirdas… - American Journal of …, 2017 - Wiley Online Library
The Ehlers–Danlos syndromes comprise a clinically and genetically heterogeneous group
of heritable connective tissue disorders, which are characterized by joint hypermobility, skin …
of heritable connective tissue disorders, which are characterized by joint hypermobility, skin …
Juvenile-onset systemic lupus erythematosus: update on clinical presentation, pathophysiology and treatment options
EMD Smith, H Lythgoe, A Midgley, MW Beresford… - Clinical …, 2019 - Elsevier
Juvenile-onset systemic lupus erythematosus (jSLE) accounts for up to 20% of all SLE
patients. Key differences between juvenile-and adult-onset (aSLE) disease include higher …
patients. Key differences between juvenile-and adult-onset (aSLE) disease include higher …
The complement system in systemic lupus erythematosus: an update
The complement system plays a major role in the autoimmune disease, systemic lupus
erythematosus (SLE). However, the role of complement in SLE is complex since it may both …
erythematosus (SLE). However, the role of complement in SLE is complex since it may both …
Early components of the complement classical activation pathway in human systemic autoimmune diseases
KE Lintner, YL Wu, Y Yang, CH Spencer… - Frontiers in …, 2016 - frontiersin.org
The complement system consists of effector proteins, regulators, and receptors that
participate in host defense against pathogens. Activation of the complement system, via the …
participate in host defense against pathogens. Activation of the complement system, via the …
Complement in autoimmune diseases
The complement system is an ancient and evolutionary conserved element of the innate
immune mechanism. It comprises of more than 20 serum proteins most of which are …
immune mechanism. It comprises of more than 20 serum proteins most of which are …
Juvenile-onset systemic lupus erythematosus (jSLE)–Pathophysiological concepts and treatment options
CM Hedrich, EMD Smith, MW Beresford - Best practice & research Clinical …, 2017 - Elsevier
The systemic autoimmune/inflammatory condition systemic lupus erythematosus (SLE)
manifests before the age of 16 years in 10–20% of all cases. Clinical courses are more …
manifests before the age of 16 years in 10–20% of all cases. Clinical courses are more …
Clinical significance of complement deficiencies
HD Pettigrew, SS Teuber… - Annals of the New York …, 2009 - Wiley Online Library
The complement system is composed of more than 30 serum and membrane‐bound
proteins, all of which are needed for normal function of complement in innate and adaptive …
proteins, all of which are needed for normal function of complement in innate and adaptive …
Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement
I Kapferer-Seebacher, M Pepin, R Werner… - The American Journal of …, 2016 - cell.com
Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal-dominant disorder
characterized by early-onset periodontitis leading to premature loss of teeth, joint …
characterized by early-onset periodontitis leading to premature loss of teeth, joint …