Outdoor air pollution and asthma

M Guarnieri, JR Balmes - The Lancet, 2014 - thelancet.com
Traffic and power generation are the main sources of urban air pollution. The idea that
outdoor air pollution can cause exacerbations of pre-existing asthma is supported by an …

A comparison of the health effects of ambient particulate matter air pollution from five emission sources

NJ Hime, GB Marks, CT Cowie - International journal of environmental …, 2018 - mdpi.com
This article briefly reviews evidence of health effects associated with exposure to particulate
matter (PM) air pollution from five common outdoor emission sources: traffic, coal-fired …

Lung homeostasis: influence of age, microbes, and the immune system

CM Lloyd, BJ Marsland - Immunity, 2017 - cell.com
Pulmonary immune homeostasis is maintained by a network of tissue-resident cells that
continually monitor the external environment, and in health, instruct tolerance to innocuous …

Cockroach allergen exposure and risk of asthma

DC Do, Y Zhao, P Gao - Allergy, 2016 - Wiley Online Library
Cockroach sensitization is an important risk factor for the development of asthma. However,
its underlying immune mechanisms and the genetic etiology for differences in allergic …

Environmental exposures and asthma development: autophagy, mitophagy, and cellular senescence

K Sachdeva, DC Do, Y Zhang, X Hu, J Chen… - Frontiers in …, 2019 - frontiersin.org
Environmental pollutants and allergens induce oxidative stress and mitochondrial
dysfunction, leading to key features of allergic asthma. Dysregulations in autophagy …

Allergy in severe asthma

SR Del Giacco, A Bakirtas, E Bel, A Custovic… - Allergy, 2017 - Wiley Online Library
It is well recognized that atopic sensitization is an important risk factor for asthma, both in
adults and in children. However, the role of allergy in severe asthma is still under debate …

Childhood asthma: pathogenesis and phenotypes

MW Pijnenburg, U Frey, JC De Jongste… - European Respiratory …, 2022 - Eur Respiratory Soc
In the pathogenesis of asthma in children there is a pivotal role for a type 2 inflammatory
response to early life exposures or events. Interactions between infections, atopy, genetic …

Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility

EB Brandt, JMB Myers, TH Acciani, PH Ryan… - Journal of allergy and …, 2015 - Elsevier
Background Exposure to traffic pollution particulate matter, predominantly diesel exhaust
particles (DEPs), increases the risk of asthma and asthma exacerbation; however, the …

Timing and duration of traffic-related air pollution exposure and the risk for childhood wheeze and asthma

KJ Brunst, PH Ryan, C Brokamp… - American journal of …, 2015 - atsjournals.org
Rationale: The timing and duration of traffic-related air pollution (TRAP) exposure may be
important for childhood wheezing and asthma development. Objectives: We examined the …

Nasal epithelial barrier disruption by particulate matter≤ 2.5 μm via tight junction protein degradation

R Zhao, Z Guo, R Zhang, C Deng, J Xu… - Journal of Applied …, 2018 - Wiley Online Library
Upper airway diseases including sinonasal disorders may be caused by exposure to fine
particulate matter (≤ 2.5 μm; PM2. 5), as proven by epidemiological studies. PM2. 5 is a …