Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …

Cytokines affect nearly every biological process; these include embryonic development,
disease pathogenesis, non‐specific response to infection, specific response to antigen …

Interleukin-2 (IL-2), the first of a series of lymphocytotrophic hormones to be recognized and
completely characterized, is pivotal for the generation and regulation of the immune …

Ki-1 is a monoclonal antibody (raised against a Hodgkin's disease-derived cell line) that, in
biopsy tissue affected by Hodgkin's disease, reacts selectively with Reed-Sternberg cells …

The anti-Tac monoclonal antibody is known to bind to the p55 chain of the human interleukin
2 receptor and to inhibit proliferation of T cells by blocking interleukin 2 binding. However …

Helper T cells control host defense against pathogens. The receptors for interleukin 12 (IL-
12), IL-4 and IL-6 are required for differentiation into the TH1, TH2 and TH17 subsets of …

Interleukin 15 (IL-15) is a novel cytokine that has recently been cloned and expressed.
Whereas it has no sequence homology with IL-2, IL-15 interacts with components of the IL-2 …

The availability of monoclonal antibodies has revived interest in immunotherapy. The ability
to influence an individual's immune state by administering immunoglobulin of the …

Regulatory T cells (Tregs) are key mediators of immune tolerance and feature prominently in
cancer. Depletion of CD25+ FoxP3+ Tregs in vivo may promote T cell cancer …

Mouse monoclonal antibodies (MAbs) have been prepared against rat T cell blasts. One
MAb called MRC OX-40 recognized an antigen that differed from any previously described …