Background Pain is reported as the leading cause of disability in the common forms of
inflammatory arthritis conditions. Acting as a key player in nociceptive processing …

Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of
anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced …

Chronic pain affects patients' physical and psychological health and quality of life, entailing
a tremendous public health challenge. Currently, drugs for chronic pain are usually …

Migraine, especially chronic migraine, is highly debilitating and still lacks effective treatment.
The persistent headache arises from activation and sensitization of primary afferent neurons …

The CC motif chemokine ligand 2 (CCL2) has been implicated in chronic pain, but its exact
mechanism of peripheral sensitization is unknown. In this study, we aimed to clarify the …

Approximately one-third of individuals with sickle cell disease (SCD) develop chronic pain.
This debilitating pain is inadequately treated because the underlying mechanisms driving …

Background Treatment of neuropathic pain is still challenging. Recent studies have
suggested that dorsal root ganglia (DRG), which carry sensory neural signals from the …

Unlike in the central nervous system (CNS), in the adult peripheral nervous system (PNS),
activation of GABA A receptors (GABA AR) is excitatory because of the relatively high …

The systemic administration of interleukin-16 (IL-16, 3–30 ng/kg) induced thermal
hyperalgesia in mice, that was prevented by the acute injection of an anti-CD4 antibody (1 …

Metamizol (also known as dipyrone or sulpyrine) is one of the non-opioid analgesics
commonly used in clinical practice in the treatment of somatic and visceral pain. Here, our …