The developmental hierarchy and scarcity of replicative slender trypanosomes in blood challenges their role in infection maintenance
SD Larcombe, EM Briggs, N Savill… - Proceedings of the …, 2023 - National Acad Sciences
The development of Trypanosoma brucei in its mammalian host is marked by a distinct
morphological change as replicative “slender” forms differentiate into cell cycle arrested …
morphological change as replicative “slender” forms differentiate into cell cycle arrested …
Advances in the Immunology of the Host–Parasite Interactions in African Trypanosomosis, including Single-Cell Transcriptomics
B Choi, HT Vu, HT Vu, M Radwanska, S Magez - Pathogens, 2024 - mdpi.com
Trypanosomes are single-celled extracellular parasites that infect mammals, including
humans and livestock, causing global public health concerns and economic losses. These …
humans and livestock, causing global public health concerns and economic losses. These …
Single-cell atlas of Leishmania development in sandflies reveals the heterogeneity of transmitted parasites and their role in infection
CMC Catta-Preta, K Ghosh, DL Sacks… - Proceedings of the …, 2024 - pnas.org
Sandfly vectors transmit Leishmania through egestion of parasites into the host skin. The
transmissible dose is shaped by Leishmania development in the sandfly gut, described as a …
transmissible dose is shaped by Leishmania development in the sandfly gut, described as a …
[HTML][HTML] Trypanosoma cruzi amastigote transcriptome analysis reveals heterogenous populations with replicating and dormant parasites
H Desale, C Herrera, E Dumonteil - Microbes and Infection, 2024 - Elsevier
Trypanosoma cruzi is a protozoan parasite causing Chagas disease, with a complex life
cycle involving different stages in insect vectors and mammalian hosts. Amastigotes are an …
cycle involving different stages in insect vectors and mammalian hosts. Amastigotes are an …
Depolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites
PA Iribarren, LA Di Marzio, MA Berazategui… - Plos …, 2024 - journals.plos.org
Trypanosoma brucei are protozoan parasites that cause sleeping sickness in humans and
nagana in cattle. Inside the mammalian host, a quorum sensing-like mechanism coordinates …
nagana in cattle. Inside the mammalian host, a quorum sensing-like mechanism coordinates …
When is a slender not a slender? The cell-cycle arrest and scarcity of slender parasites challenges the role of bloodstream trypanosomes in infection maintenance
The development of Trypanosoma brucei in its mammalian host is marked by a distinct
morphological change as replicative “slender” forms differentiate into cell-cycle arrested …
morphological change as replicative “slender” forms differentiate into cell-cycle arrested …
The Trypanosoma cruzi cell atlas; a single-cell resource for understanding parasite population heterogeneity and differentiation.
R Laidlaw, MG Sanchez, JDS Pacheco, LDS Paradela… - bioRxiv, 2024 - biorxiv.org
Trypanosoma cruzi, the causative agent of Chagas disease, exhibits a complex life cycle
with multiple hosts, stages and differentiation steps, all associated with extensive …
with multiple hosts, stages and differentiation steps, all associated with extensive …
R-loops acted on by RNase H1 are a determinant of chromosome length-associated DNA replication timing and genome stability in Leishmania
Genomes in eukaryotes normally undergo DNA replication in a choreographed temporal
order, resulting in early and late replicating chromosome compartments. Leishmania, a …
order, resulting in early and late replicating chromosome compartments. Leishmania, a …
SUMO chains depolymerization induces slender to stumpy differentiation in T. brucei bloodstream parasites
PA Iribarren, LA Di Marzio, MA Berazategui, A Saura… - bioRxiv, 2023 - biorxiv.org
Trypanosoma brucei are extracellular protozoan parasites transmitted by tsetse flies that
cause sleeping sickness in humans and nagana in cattle. Inside the mammalian host …
cause sleeping sickness in humans and nagana in cattle. Inside the mammalian host …
[PDF][PDF] Single-cell atlas of Leishmania major development in the sandfly vector reveals the heterogeneity of transmitted parasites and their role in infection
C Catta-Preta, K Ghosh, D Sacks, T Ferreira - 2024 - researchgate.net
Leishmania development in the sand y vector is predominantly characterized as a series of
sequential promastigote morphotypes. Apart from isolated mammal-infective metacyclic …
sequential promastigote morphotypes. Apart from isolated mammal-infective metacyclic …