A large number of genes associated with various cancer types contain single nucleotide
polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' …

How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …

Cancer is widely perceived as a heterogeneous group of disorders with markedly different
biological properties, which are caused by a series of clonally selected genetic changes in …

The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug
response and adverse reactions to a great extent. This variation includes copy number …

Epigenetic gene inactivation in transformed cells involves many 'belts of silencing'. One of
the best-known lesions of the malignant cell is the transcriptional repression of tumor …

Chronic inflammation, regardless of infectious agents, plays important roles in the
development of various cancers, particularly in digestive organs, including Helicobacter …

Within 2–3 months of in vitro culture‐expansion, mesenchymal stromal cells (MSC) undergo
replicative senescence characterized by cell enlargement, loss of differentiation potential …

Endometriosis is a common gynecologic disorder with an enigmatic etiopathogenesis.
Although it has been proposed that endometriosis is a hormonal disease, an autoimmune …

The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our
understanding of chromatin structure, histone modification, transcriptional activity and DNA …

Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with
many human tumour types. New techniques have been developed to perform genome-wide …