[HTML][HTML] Single nucleotide polymorphisms and cancer susceptibility
NA Deng, H Zhou, H Fan, Y Yuan - Oncotarget, 2017 - ncbi.nlm.nih.gov
A large number of genes associated with various cancer types contain single nucleotide
polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' …
polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' …
Methyl-CpG-binding domain proteins: readers of the epigenome
How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
The epigenetic progenitor origin of human cancer
Cancer is widely perceived as a heterogeneous group of disorders with markedly different
biological properties, which are caused by a series of clonally selected genetic changes in …
biological properties, which are caused by a series of clonally selected genetic changes in …
Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects
M Ingelman-Sundberg, SC Sim, A Gomez… - Pharmacology & …, 2007 - Elsevier
The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug
response and adverse reactions to a great extent. This variation includes copy number …
response and adverse reactions to a great extent. This variation includes copy number …
Epigenetic gene silencing in cancer: the DNA hypermethylome
M Esteller - Human molecular genetics, 2007 - academic.oup.com
Epigenetic gene inactivation in transformed cells involves many 'belts of silencing'. One of
the best-known lesions of the malignant cell is the transcriptional repression of tumor …
the best-known lesions of the malignant cell is the transcriptional repression of tumor …
Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation
T Chiba, H Marusawa, T Ushijima - Gastroenterology, 2012 - Elsevier
Chronic inflammation, regardless of infectious agents, plays important roles in the
development of various cancers, particularly in digestive organs, including Helicobacter …
development of various cancers, particularly in digestive organs, including Helicobacter …
DNA methylation pattern changes upon long‐term culture and aging of human mesenchymal stromal cells
Within 2–3 months of in vitro culture‐expansion, mesenchymal stromal cells (MSC) undergo
replicative senescence characterized by cell enlargement, loss of differentiation potential …
replicative senescence characterized by cell enlargement, loss of differentiation potential …
Epigenetics of endometriosis
SW Guo - Molecular human reproduction, 2009 - academic.oup.com
Endometriosis is a common gynecologic disorder with an enigmatic etiopathogenesis.
Although it has been proposed that endometriosis is a hormonal disease, an autoimmune …
Although it has been proposed that endometriosis is a hormonal disease, an autoimmune …
Cancer epigenetics
PW Laird - Human molecular genetics, 2005 - academic.oup.com
The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our
understanding of chromatin structure, histone modification, transcriptional activity and DNA …
understanding of chromatin structure, histone modification, transcriptional activity and DNA …
Detection and interpretation of altered methylation patterns in cancer cells
T Ushijima - Nature Reviews Cancer, 2005 - nature.com
Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with
many human tumour types. New techniques have been developed to perform genome-wide …
many human tumour types. New techniques have been developed to perform genome-wide …