Polygenic Risk Scores for Glaucoma Onset in the Ocular Hypertension Treatment Study
RK Singh, Y Zhao, T Elze, J Fingert… - JAMA …, 2024 - jamanetwork.com
Importance Primary open-angle glaucoma (POAG) is a highly heritable disease, with 127
identified risk loci to date. Polygenic risk score (PRS) may provide a clinically useful …
identified risk loci to date. Polygenic risk score (PRS) may provide a clinically useful …
[HTML][HTML] Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks
JS Yun, SH Jung, SN Lee, SM Jung, HH Won… - Journal of Translational …, 2024 - Springer
Background Glaucoma is a leading cause of worldwide irreversible blindness. Considerable
uncertainty remains regarding the association between a variety of phenotypes and the …
uncertainty remains regarding the association between a variety of phenotypes and the …
[HTML][HTML] How genome-wide association studies transform care for patients at risk of glaucoma
N Zebardast, JL Wiggs - Expert Review of Ophthalmology, 2024 - Taylor & Francis
Glaucoma, the most common cause of irreversible blindness worldwide is one of the most
heritable of all complex human diseases with an estimated heritability of 70%[1]. Diagnosis …
heritable of all complex human diseases with an estimated heritability of 70%[1]. Diagnosis …