Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

The somatic mutation theory of aging posits that the accumulation of mutations in the genetic
material of somatic cells as a function of time results in a decrease in cellular function. In …

The diversity and complexity of the human brain are widely assumed to be encoded within a
constant genome. Somatic gene recombination, which changes germline DNA sequences to …

Most solid tumors are aneuploid, and it has been proposed that aneuploidy is the
consequence of an elevated rate of chromosome missegregation in a process called …

An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells.
Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has …

DNA damage is correlated with and may drive the ageing process. Neurons in the brain are
postmitotic and are excluded from many forms of DNA repair; therefore, neurons are …

The study of human developmental microcephaly is providing important insights into brain
development. It has become clear that developmental microcephalies are associated with …

The science of genetics is undergoing a paradigm shift. Recent discoveries, including the
activity of retrotransposons, the extent of copy number variations, somatic and chromosomal …

Classical studies in genetics involving aneuploidy and ploidy comparisons and sex-
determination mechanisms indicated a balance phenomenon such that changes of …

The mouse brain contains genetically distinct cells that differ with respect to chromosome
number manifested as aneuploidy (Rehen et al., 2001); however, the relevance to humans …