Iron, glucose and fat metabolism and obesity: an intertwined relationship

C Hilton, R Sabaratnam, H Drakesmith… - International Journal of …, 2023 - nature.com
A bidirectional relationship exists between adipose tissue metabolism and iron regulation.
Total body fat, fat distribution and exercise influence iron status and components of the iron …

[HTML][HTML] Iron and liver fibrosis: Mechanistic and clinical aspects

KJ Mehta, SJ Farnaud, PA Sharp - World journal of …, 2019 - ncbi.nlm.nih.gov
Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts
normal liver functionality. It is a pathological stage in several untreated chronic liver …

Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease

S van Raaij, R van Swelm, K Bouman, M Cliteur… - Scientific reports, 2018 - nature.com
Iron is suggested to play a detrimental role in the progression of chronic kidney disease
(CKD). The kidney recycles iron back into the circulation. However, the localization of …

Anaemia, a common but often unrecognized risk in diabetic patients: a review

A Angelousi, E Larger - Diabetes & metabolism, 2015 - Elsevier
Anaemia in patients with diabetes, both type 1 and type 2, is a frequent clinical finding. The
mechanisms of anaemia are multifactorial and often not very well understood. Iatrogenic …

Hepcidin is directly regulated by insulin and plays an important role in iron overload in streptozotocin-induced diabetic rats

H Wang, H Li, X Jiang, W Shi, Z Shen, M Li - Diabetes, 2014 - Am Diabetes Assoc
Iron overload is frequently observed in type 2 diabetes mellitus (DM2), but the underlying
mechanisms remain unclear. We hypothesize that hepcidin may be directly regulated by …

Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes

M Ouni, F Eichelmann, M Jähnert, C Krause… - Molecular …, 2023 - Elsevier
Objectives Better disease management can be achieved with earlier detection through
robust, sensitive, and easily accessible biomarkers. The aim of the current study was to …

[HTML][HTML] Iron: An underrated factor in aging

D Mangan - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Iron is an essential element for virtually all living organisms, but its reactivity also makes it
potentially harmful. Iron accumulates with aging, and is associated with many age-related …

Low hepcidin in liver fibrosis and cirrhosis; a tale of progressive disorder and a case for a new biochemical marker

D Vela - Molecular Medicine, 2018 - Springer
Liver fibrosis is a precursor of liver cirrhosis, which is associated with increased mortality.
Though liver biopsy remains the gold standard for the diagnosis of fibrosis, noninvasive …

Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells

M Hamad, AK Mohammed, MY Hachim… - Molecular and Cellular …, 2021 - Elsevier
Iron overload promotes the generation of reactive oxygen species (ROS). Pancreatic β-cells
can counter oxidative stress through multiple anti-oxidant responses. Herein, RNA …

[HTML][HTML] Hepcidin-A novel biomarker with changing trends

A Kali, MVP Charles, RSK Seetharam - Pharmacognosy reviews, 2015 - ncbi.nlm.nih.gov
Hepcidin is a novel peptide hormone of hepatic origin. It has a crucial role in iron
metabolism. The causative association of this peptide in anemia and iron overloading states …