Cardiovascular diseases crossroads: cGAS-STING signaling and disease progression

MS Khan, SU Khan, SU Khan, M Suleman… - Current Problems in …, 2024 - Elsevier
It is now widely accepted that inflammation is critical in cardiovascular diseases (CVD).
Here, studies are being conducted on how cyclic GMP-AMP synthase (cGAS), a component …

[HTML][HTML] Enhancements of Bcl-2/mTOR/ERK1/2 activities by antioxidant mechanisms confer cardioprotection on Ginkgo biloba supplement against isoprenaline …

JN Asiwe, B Ben-Azu, GD Yovwin, SE Ehebha… - Pharmacological …, 2023 - Elsevier
Background Myocyte necrosis and apoptosis can be severely induced by acute adrenergic
stimulation due to the activation of several cell signalling pathways. However, uncertainty …

Trilobatin attenuates cerebral ischaemia/reperfusion‐induced blood–brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive

L Feng, Y Li, M Lin, D Xie, Y Luo… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Blood–brain barrier (BBB) breakdown is one of the
crucial pathological changes of cerebral ischaemia–reperfusion (I/R) injury. Trilobatin (TLB) …

[HTML][HTML] Cardioprotective potential of oleuropein, hydroxytyrosol, oleocanthal and their combination: Unravelling complementary effects on acute myocardial infarction …

A Christodoulou, PE Nikolaou, L Symeonidi… - Redox Biology, 2024 - Elsevier
Clinical studies have previously established the role of olive products in cardiovascular
disease (CVD) prevention, whilst the identification of the responsible constituents for the …

Cardioprotective Effect of Flibanserin against Isoproterenol-Induced Myocardial Infarction in Female Rats: Role of Cardiac 5-HT2A Receptor Gene/5-HT/Ca2+ …

MI Ahmed, HMA Abdelrazek, YM Moustafa… - Pharmaceuticals, 2023 - mdpi.com
Myocardial infarction (MI) is a life-threatening ischemic disease and is one of the leading
causes of morbidity and mortality worldwide. Serotonin (5-HT) release during myocardial …

[HTML][HTML] Pleiotropic attenuating effect of Ginkgo biloba against isoprenaline-induced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na+, K+-ATPase …

JN Asiwe, AA Ojetola, NE Ekene, E Osirim… - Chinese Herbal …, 2024 - Elsevier
Objective Myocardial infarction (MI) is linked to an imbalance in the supply and demand of
blood oxygen in the heart muscles. Beta-blockers and calcium antagonists are just two of the …

Sophocarpine alleviates isoproterenol-induced kidney injury by suppressing inflammation, apoptosis, oxidative stress and fibrosis

W Zhou, Y Fu, JS Xu - Molecules, 2022 - mdpi.com
One of the most common diseases affecting people and leading to high morbidity is kidney
injury. The alleviation of inflammation and apoptosis is considered a potential therapeutic …

A Comprehensive Review on Molecular Mechanisms, Treatments, and Brief Role of Natural Products in Hepatocellular Cancer

L Jiang, Q Meng, L Liu, W Li - Natural Product …, 2024 - journals.sagepub.com
Most initial liver cancers are hepatocellular carcinomas (HCC), which make up the vast
majority of cases. Hepatitis B or C virus infection as well as alcohol consumption is among …

Abatacept: A Promising Repurposed Solution for Myocardial Infarction‐Induced Inflammation in Rat Models

VK Verma, E Mutneja, S Malik, AK Sahu… - Oxidative Medicine …, 2024 - Wiley Online Library
Myocardial infarction (MI) is irreversible damage to the myocardial tissue caused by
prolonged ischemia/hypoxia, subsequently leading to loss of contractile function and …

Integrated serum pharmacochemistry with network pharmacology and pharmacological validation to elucidate the mechanism of yiqitongmai decoction (YQTMD) …

H Yu, N Wang, X Zhao, L Han, J Peng - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Yiqitongmai decoction (YQTMD), a classic TCM, has been
widely used in clinical treatment for MI. However, it is still difficult to clarify the potential active …