Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial
infection that elicits an extraordinary range of cellular immune responses in humans. The …

Neuropathy and related disabilities are the major medical consequences of leprosy, which
remains a global medical concern. Despite major advances in understanding the …

Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate
intracellular organism, and over 200,000 new cases occur every year. M. leprae parasitizes …

The antibiotic era started in the 1940s and changed the profile of infectious diseases and
human demography. The burgeoning classes and numbers promised much and elimination …

Leprosy control depends solely on case detection and treatment with multi-drug therapy
(MDT). 1–3 This strategy is based on the principle that identifying and treating chronic …

Leprosy is caused by Mycobacterium leprae. Currently, leprosy control is mainly based on
WHO-recommended multi-drug treatment; thus, emergence of drug resistance is a major …

The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium
leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological …

Introduction The magnitude of drug resistance in Mycobacterium leprae to dapsone,
rifampicin, and ofloxacin was studied in three Southeast Asian countries with a high …

Clofazimine (CFZ), an old hydrophobic riminophenazine, has a wide range of
antimycobacterial activity ranging from leprosy to nontuberculous mycobacterial diseases …

Although curable, leprosy requires better diagnostic and prognostic tools to accompany
therapeutic strategies. We evaluated the serum samples of leprosy patients from Venezuela …