Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …

Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

Metabolic-associated fatty liver disease (MAFLD) is a spectrum of clinical manifestations
ranging from benign steatosis to cirrhosis. A key event in the pathophysiology of MAFLD is …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Cancer mortality primarily stems from metastatic recurrence, emphasizing the urgent need
for developing effective metastasis-targeted immunotherapies. To better understand the …

Liver fibrosis results from chronic liver injury triggered by factors such as viral infection,
excess alcohol intake, and lipid accumulation. However, the mechanisms underlying liver …

Accumulation of lipotoxic lipids, such as free cholesterol, induces hepatocyte death and
subsequent inflammation and fibrosis in the pathogenesis of nonalcoholic steatohepatitis …

Asthma is a heterogenous chronic inflammatory lung disease with endotypes that manifest
different immune system profiles, severity, and responses to current therapies. Regardless of …