Therapeutic targeting of the tumor microenvironment
L Bejarano, MJC Jordāo, JA Joyce - Cancer discovery, 2021 - AACR
Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …
promising approach for cancer treatment in recent years due to the critical roles of the TME …
Role of matrix metalloproteinases in angiogenesis and cancer
S Quintero-Fabián, R Arreola… - Frontiers in …, 2019 - frontiersin.org
During angiogenesis, new vessels emerge from existing endothelial lined vessels to
promote the degradation of the vascular basement membrane and remodel the extracellular …
promote the degradation of the vascular basement membrane and remodel the extracellular …
Biodegradable NIR‐II Pseudo Conjugate Polymeric Nanoparticles Amplify Photodynamic Immunotherapy via Alleviation of Tumor Hypoxia and Tumor‐Associated …
J Wan, X Zhang, D Tang, T Liu, H Xiao - Advanced Materials, 2023 - Wiley Online Library
Photodynamic therapy (PDT) has achieved great success in cancer treatment. Despite its
great promise, the efficacy of photodynamic immunotherapy can be limited by the hypoxia in …
great promise, the efficacy of photodynamic immunotherapy can be limited by the hypoxia in …
VEGF in signaling and disease: beyond discovery and development
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our
understanding of vasculogenesis and angiogenesis during development and physiological …
understanding of vasculogenesis and angiogenesis during development and physiological …
The local microenvironment drives activation of neutrophils in human brain tumors
Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors in
substantial numbers. However, their precise functions in different cancer types remain …
substantial numbers. However, their precise functions in different cancer types remain …
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges
D Fukumura, J Kloepper, Z Amoozgar… - Nature reviews Clinical …, 2018 - nature.com
Immunotherapy has emerged as a major therapeutic modality in oncology. Currently,
however, the majority of patients with cancer do not derive benefit from these treatments …
however, the majority of patients with cancer do not derive benefit from these treatments …
Tumor angiogenesis and vascular normalization: alternative therapeutic targets
C Viallard, B Larrivée - Angiogenesis, 2017 - Springer
Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …
The microenvironmental landscape of brain tumors
DF Quail, JA Joyce - Cancer cell, 2017 - cell.com
The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer
progression in primary and metastatic brain malignancies. The unique properties of this …
progression in primary and metastatic brain malignancies. The unique properties of this …
Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
Transport of drugs from blood vessels to tumour tissue
MW Dewhirst, TW Secomb - Nature Reviews Cancer, 2017 - nature.com
The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …