The oral microbiome: Role of key organisms and complex networks in oral health and disease

L Sedghi, V DiMassa, A Harrington… - Periodontology …, 2021 - Wiley Online Library
States of oral health and disease reflect the compositional and functional capacities of, as
well as the interspecies interactions within, the oral microbiota. The oral cavity exists as a …

Biology of Streptococcus mutans- Derived Glucosyltransferases: Role in Extracellular Matrix Formation of Cariogenic Biofilms

WH Bowen, H Koo - Caries research, 2011 - karger.com
The importance of Streptococcus mutans in the etiology and pathogenesis of dental caries is
certainly controversial, in part because excessive attention is paid to the numbers of S …

Dextran-coated iron oxide nanoparticles as biomimetic catalysts for localized and pH-activated biofilm disruption

PC Naha, Y Liu, G Hwang, Y Huang, S Gubara… - ACS …, 2019 - ACS Publications
Biofilms are surface-attached bacterial communities embedded within an extracellular matrix
that create localized and protected microenvironments. Acidogenic oral biofilms can …

Symbiotic Relationship between Streptococcus mutans and Candida albicans Synergizes Virulence of Plaque Biofilms In Vivo

ML Falsetta, MI Klein, PM Colonne… - Infection and …, 2014 - Am Soc Microbiol
Streptococcus mutans is often cited as the main bacterial pathogen in dental caries,
particularly in early-childhood caries (ECC). S. mutans may not act alone; Candida albicans …

Spatial mapping of polymicrobial communities reveals a precise biogeography associated with human dental caries

D Kim, JP Barraza, RA Arthur, A Hara… - Proceedings of the …, 2020 - National Acad Sciences
Tooth decay (dental caries) is a widespread human disease caused by microbial biofilms.
Streptococcus mutans, a biofilm-former, has been consistently associated with severe …

The exopolysaccharide matrix: a virulence determinant of cariogenic biofilm

H Koo, ML Falsetta, MI Klein - Journal of dental research, 2013 - journals.sagepub.com
Many infectious diseases in humans are caused or exacerbated by biofilms. Dental caries is
a prime example of a biofilm-dependent disease, resulting from interactions of …

A cross-talk between diet and the oral microbiome: balance of nutrition on inflammation and immune system's response during periodontitis

S Santonocito, A Giudice, A Polizzi, G Troiano… - Nutrients, 2022 - mdpi.com
Over the last few decades, studies on the oral microbiome have increased awareness that
the balance between the host and the microbial species that coexist in it is essential for oral …

Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms

MI Klein, G Hwang, PHS Santos… - Frontiers in cellular …, 2015 - frontiersin.org
Biofilms are highly structured microbial communities that are enmeshed in a self-produced
extracellular matrix. Within the complex oral microbiome, Streptococcus mutans is a major …

pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence

B Horev, MI Klein, G Hwang, Y Li, D Kim, H Koo… - ACS …, 2015 - ACS Publications
Development of effective therapies to control oral biofilms is challenging, as topically
introduced agents must avoid rapid clearance from biofilm–tooth interfaces while targeting …

The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm

J Xiao, MI Klein, ML Falsetta, B Lu… - PLoS …, 2012 - journals.plos.org
Virulent biofilms are responsible for a range of infections, including oral diseases. All
biofilms harbor a microbial-derived extracellular-matrix. The exopolysaccharides (EPS) …