Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

Nitric oxide synthases are the major sources of nitric oxide, a critical signaling molecule
involved in a wide range of cellular and physiological processes. These enzymes comprise …

The well-developed synthetic chemistry of ruthenium, particularly with ammine, amine and
imine ligands, provides for many approaches to innovative new metallopharmaceuticals …

Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous
system. With recognition of its roles in synaptic plasticity (long-term potentiation, LTP; long …

As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still
thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the …

The gas NO is a messenger that modulates neuronal function. The use of NO donors and
NO synthase inhibitors as pharmacological tools revealed that this free radical is probably …

Nitric oxide (NO) is a molecule with pleiotropic effects in different tissues. NO is synthesized
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …

The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains
controversial in part because of the use of nonselective agents that block NO formation in …

NO was first characterized in the CNS as the intercellular messenger mediating the increase
in cyclic GMP levels that follows activation of glutamate receptors (Garthwaite et al., 1988) …

Insulin is best known for its action on peripheral insulin target tissues such as the adipocyte,
muscle and liver to regulate glucose homeostasis. In the central nervous system (CNS) …