Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …

New genome assemblies have been arriving at a rapidly increasing pace, thanks to
decreases in sequencing costs and improvements in third-generation sequencing …

Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …

The human genome encodes some 350 Krüppel-associated box (KRAB) domain-containing
zinc-finger proteins (KZFPs), the products of a rapidly evolving gene family that has been …

The ability to modify multiple genetic elements simultaneously would help to elucidate and
control the gene interactions and networks underlying complex cellular functions. However …

Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of
transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB …

Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene
expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling …

Throughout evolution primate genomes have been modified by waves of retrotransposon
insertions,,. For each wave, the host eventually finds a way to repress retrotransposon …

Subcellular localization is a main determinant of protein function; however, a global view of
cellular proteome organization remains relatively unexplored. We have developed a robust …