Newly synthesized proteins require the assistance of molecular chaperones to efficiently fold
into functional three-dimensional structures in the crowded environment of the cell. At first …

ECOLOGY The scope of mycoplasmology has been con-siderably widened during the last
few years. Not only has the total number of species been brought to over 60 (329), but …

Initially discovered in the context of immunomodulation, peptidyl-prolyl cis/trans isomerases
(PPIases) were soon identified as enzymes catalyzing the rate-limiting protein folding step at …

[Frontiers in Bioscience 9, 3453-3478, September 1, 2004] 3453 INSIGHTS INTO THE
CATALYTIC MECHANISM OF PEPTIDYL PROLYL CIS/TRAN Page 1 [Frontiers in …

Immunophilins are defined as receptors for immunosuppressive drugs including cyclosporin
A, FK506, and rapamycin. The cyclosporin A receptors are referred to as cyclophilins (CYPs) …

Mollicutes is a class of parasitic bacteria that have evolved from a common Firmicutes
ancestor mostly by massive genome reduction. With genomes under 1 Mbp in size, most …

SlyD is a putative folding helper protein from the Escherichia coli cytosol, which consists of
an N-terminal prolyl isomerase domain of the FKBP type and a presumably unstructured C …

Infectious diseases are a major cause of morbidity and mortality worldwide, exacerbated by
increasing antibiotic resistance in many bacterial species. The development of drugs with …

The trigger factor of Escherichia coli is a prolyl isomerase and a chaperone. It interacts with
the ribosome and affects the folding of newly formed protein chains. Therefore, the dynamics …

This highly illustrated book provides an up-to-date description of the structure and function of
the translation system including ribosomes, tRNAs, translation factors, antibiotics and …