New trends in the biocatalytic production of nucleosidic active pharmaceutical ingredients using 2′-deoxyribosyltransferases
Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …
Purine and pyrimidine salvage pathway in thermophiles: a valuable source of biocatalysts for the industrial production of nucleic acid derivatives
J Del Arco, J Fernández-Lucas - Applied microbiology and biotechnology, 2018 - Springer
Due to their similarity to natural counterparts, nucleic acid derivatives (nucleobases,
nucleosides, and nucleotides, among others) are interesting molecules for pharmaceutical …
nucleosides, and nucleotides, among others) are interesting molecules for pharmaceutical …
Structural and functional characterization of thermostable biocatalysts for the synthesis of 6-aminopurine nucleoside-5′-monophospate analogues
J Del Arco, E Pérez, H Naitow, Y Matsuura… - Bioresource …, 2019 - Elsevier
The present work describes the functional and structural characterization of adenine
phosphoribosyltransferase 2 from Thermus thermophilus HB8 (TtAPRT2). The combination …
phosphoribosyltransferase 2 from Thermus thermophilus HB8 (TtAPRT2). The combination …
Mechanism of diol dehydration by a promiscuous radical‐SAM enzyme homologue of the antiviral enzyme viperin (RSAD2)
K Honarmand Ebrahimi, JS Rowbotham… - …, 2020 - Wiley Online Library
Deoxynucleotides are an important class of drugs because they interfere with the
metabolism of nucleotides, and their incorporation into DNA or RNA terminates cell division …
metabolism of nucleotides, and their incorporation into DNA or RNA terminates cell division …
One-pot multi-enzymatic production of purine derivatives with application in pharmaceutical and food industry
J Acosta, J Del Arco, S Martinez-Pascual… - Catalysts, 2018 - mdpi.com
Biocatalysis reproduce nature's synthetic strategies in order to synthesize different organic
compounds. Natural metabolic pathways usually involve complex networks to support …
compounds. Natural metabolic pathways usually involve complex networks to support …
Purine and pyrimidine phosphoribosyltransferases: a versatile tool for enzymatic synthesis of nucleoside-5'-monophosphates
JD Arco, J Fernandez-Lucas - Current Pharmaceutical Design, 2017 - benthamdirect.com
Background: In recent years, enzymatic methods have shown to be an efficient and
sustainable alternative for the synthesis of nucleosides and nucleoside-5'-monophosphates …
sustainable alternative for the synthesis of nucleosides and nucleoside-5'-monophosphates …
Hypoxanthine-Guanine Phosphoribosyltransferase/adenylate Kinase From Zobellia galactanivorans: A Bifunctional Catalyst for the Synthesis of Nucleoside-5 …
J Acosta, J Del Arco, ML Del Pozo… - … in Bioengineering and …, 2020 - frontiersin.org
In our search for novel biocatalysts for the synthesis of nucleic acid derivatives, we found a
good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase …
good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase …
One-pot, one-step production of dietary nucleotides by magnetic biocatalysts
J Del Arco, S Martínez-Pascual, VJ Clemente-Suárez… - Catalysts, 2018 - mdpi.com
The enzymatic synthesis of nucleotides offers several advantages over traditional multistep
chemical methods, such as stereoselectivity, regioselectivity, enantioselectivity, simple …
chemical methods, such as stereoselectivity, regioselectivity, enantioselectivity, simple …
Taylor-made production of pyrimidine nucleoside-5′-monophosphate analogues by highly stabilized mutant uracil phosphoribosyltransferase from Toxoplasma …
J Acosta, K Nguyen, RC Spitale… - Bioresource …, 2021 - Elsevier
Nowadays, enzymatic synthesis of nucleotides is an efficient and sustainable alternative to
chemical methodologies. In this regard, after the biochemical characterization of wild-type …
chemical methodologies. In this regard, after the biochemical characterization of wild-type …
N-Ribosyltransferase From Archaeoglobus veneficus: A Novel Halotolerant and Thermostable Biocatalyst for the Synthesis of Purine Ribonucleoside Analogs
Nucleoside-2′-deoxyribosyl-transferases (NDTs) catalyze a transglycosylation reaction
consisting of the exchange of the 2′-deoxyribose moiety between a purine and/or …
consisting of the exchange of the 2′-deoxyribose moiety between a purine and/or …