[HTML][HTML] Single-cell sequencing of brain cell transcriptomes and epigenomes

EJ Armand, J Li, F Xie, C Luo, EA Mukamel - Neuron, 2021 - cell.com
Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …

[HTML][HTML] A multimodal cell census and atlas of the mammalian primary motor cortex

Principal manuscript editors, Analysis coordination… - Nature, 2021 - nature.com
Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

[HTML][HTML] Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays

A Chen, S Liao, M Cheng, K Ma, L Wu, Y Lai, X Qiu… - Cell, 2022 - cell.com
Spatially resolved transcriptomic technologies are promising tools to study complex
biological processes such as mammalian embryogenesis. However, the imbalance between …

[HTML][HTML] A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation

Z Yao, CTJ Van Velthoven, TN Nguyen, J Goldy… - Cell, 2021 - cell.com
The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …

[HTML][HTML] Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram

T Biancalani, G Scalia, L Buffoni, R Avasthi, Z Lu… - Nature …, 2021 - nature.com
Charting an organs' biological atlas requires us to spatially resolve the entire single-cell
transcriptome, and to relate such cellular features to the anatomical scale. Single-cell and …

[HTML][HTML] Cellular anatomy of the mouse primary motor cortex

R Muñoz-Castañeda, B Zingg, KS Matho, X Chen… - Nature, 2021 - nature.com
An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …

[HTML][HTML] Phenotypic variation of transcriptomic cell types in mouse motor cortex

F Scala, D Kobak, M Bernabucci, Y Bernaerts… - Nature, 2021 - nature.com
Cortical neurons exhibit extreme diversity in gene expression as well as in morphological
and electrophysiological properties 1, 2. Most existing neural taxonomies are based on …

gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration

J Orvis, B Gottfried, J Kancherla, RS Adkins, Y Song… - Nature …, 2021 - nature.com
To the Editor—Biologists are important stakeholders in genomic data, both as data
generators and as users of genomic data resources. Tools to efficiently visualize and …

[HTML][HTML] DNA methylation atlas of the mouse brain at single-cell resolution

H Liu, J Zhou, W Tian, C Luo, A Bartlett, A Aldridge… - Nature, 2021 - nature.com
Mammalian brain cells show remarkable diversity in gene expression, anatomy and
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …

GluN3A NMDA receptor subunits: more enigmatic than ever?

O Crawley, MJ Conde‐Dusman… - The Journal of …, 2022 - Wiley Online Library
Non‐conventional N‐methyl‐d‐aspartate receptors (NMDARs) containing GluN3A subunits
have unique biophysical, signalling and localization properties within the NMDAR family …